核心——有机制剂和分析实验室服务-猫眼课题宝

核心——有机制剂和分析实验室服务

批准号：

6563808

负责人：

KAMAL N TIWARI

金额：

$22.84万

依托单位：

SOUTHERN RESEARCH INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

2002

资助国家：

美国

项目状态：

已结题

起止时间：

2002-02-01 至 2003-01-31

来源：

https://reporter.nih.gov/project-details/6563808

关键词：

analytical chemistry antineoplastics biomedical facility chemical synthesis drug design /synthesis /production high throughput technology nucleoside analog nucleoside triphosphate organic chemicals prodrugs

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APPLICANT'S DESCRIPTION: (provided by Applicant) The overall goals of this core are twofold. The main goal is to provide a mechanism for the larger scale synthesis or resynthesis of intermediates and final products to be used by all of the projects in the grant. An additional goal is to provide a mechanism 1) for the purchase of disposable items for our Analytical Services Group to use for all of the synthetic organic projects; and 2) for defraying the appropriate percentage of maintenance time required for keeping our instruments in top operating condition. As part of this first goal, we will also synthesize needed triphosphates of nucleosides for biological experiments. In the beginning, we need to synthesize the triphosphate of two nucleosides, 4(-thio-ara-C and 2-chloro-2(-deoxy-2(-fluoroadenosine, for mechanism of action studies in Project 16. The triphosphates of other nucleosides will be synthesized as needed.

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