PRESENTATIONS BY G ALLAN JOHNSON, PH D: MR MICROSCOPY & 3 D VISUALIZ

膝关节半月板的损伤或损伤导致进行性 关节软骨退行性变，其特征是 骨性关节炎。我们提出了一种自体半月板移植 髂胫筋膜可抑制膝关节软骨退变 半月板切除后。在这项为期24个月的拟议计划中，我们计划 半月板切除后犬膝关节中下列指标的量化 (n=15)和自体骨移植后(n=15)：(1)机械 关节软骨的特性；(2)材料特性 再生半月板；(3)原生和再生的三维几何 半月板使用磁共振显微镜。通过这种方式，我们将比较 软骨退变状态与半月板功能参数 和解剖学，了解“未经治疗”和“已治疗”之间的区别 外科手术小组。我们的长期目标是发展量化 方法评价自体半月板移植的疗效。 以及其他外科治疗(例如，同种异体移植)以防止 膝关节的骨性关节炎。这方面的实验证据 成功抑制退行性变的治疗方法 动物模型将促进临床治疗的选择。

Damage or injury of the knee meniscus leads to progressive degeneration of articular cartilage in which is characteristic of osteoarthritis. We propose that a meniscal autograft constructed from iliotibial fascia will inhibit cartilage degeneration in the knee following meniscectomy. In this 24-month proposed project, we plan to quantify the following in the canine knee following meniscectomy (n=15), and following autograft implantation (n=15): (1) mechanical properties of articular cartilage; (2) material properties of regenerate menisci; and (3) the 3-D geometry of native and regenerate meniscus using MR microscopy. In this manner, we will compare the state of cartilage degeneration, and parameters of meniscal function and anatomy, for differences between "untreated" and "treated" surgical groups. The long-term objectives are to develop quantitative methods to evaluate the efficacy of the proposed meniscal autograft, as well as other surgical treatments (e.g., allograft) for preventing osteoarthritis in the knee joint. Experimental evidence of such treatments which are successful for inhibiting degeneration in an animal model would promote options for clinical treatment.