HYPERPOLARIZED GAS IMAGING AT THE DIFFUSION LIMIT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们将开发多通道（1H/3 He和129 He/1H）3D径向编码，用于在扩散和磁化率限制所造成的空间分辨率下对小鼠肺进行体内成像。 为了实现这一目标，我们将整合三项紧密结合的技术改进： --我们将把双通道射频线圈集成到我们的成像链中，以便在85和64 MHz下同时采集，以提高灵敏度。 --我们将安装新的更高强度梯度（400 mT/m），以减少扩散的影响。 --我们将优化3D（双通道）径向采集序列，以限制磁化率的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will develop multi-channel (1H/3He and 129Xe/1H) 3D radial encoding for in vivo imaging of the mouse lung at the spatial resolution posed by diffusion and susceptibility limits. To achieve this aim, we will integrate three tightly coupled improvements in technology: -- We will integrate a dual-channel rf coil into our imaging chain for simultaneous acquisition @ 85 and 64 MHz to improve the sensitivity. -- We will install new higher strength gradients (400 mT/m) to reduce the impact of diffusion. -- We will optimize a 3D (dual-channel) radial acquisition sequence to limit the effects of susceptibility.