Agilent Direct Drive 9.4T MRS/MRI Console

描述(由申请人提供)： 我们建议将已有12年历史的GE(Signa LX)MRI控制台替换为最先进的Varian/Agilent控制台，以支持世界各地的科学家进行磁共振显微镜检查。与现有的9.4T磁铁和新一代低温射频探头相结合，这一真正独特的成像系统将支持扩散极限(&lt；10微米)的空间分辨率。一种新的扩散张量成像策略将提供具有各向同性空间分辨率&20微米的常规成像。这笔资源将用27笔NIH补助金支持18名由NIH资助的调查人员的工作。该系统将允许我们将常规磁共振显微镜的吞吐量提高3倍以上，将有限视野的空间分辨率提高近10倍，并将扩散张量显微镜的扫描时间减少至少4倍。 与公共卫生相关：人类基因组测序开启了分子医学的一个全新时代，面临的最关键问题之一是将测序的人类基因组中的大量信息与物理表达-表型-联系起来。老鼠模型是了解这一点的关键工具之一。磁共振组织学将被用来了解一些最关键的模型的大脑形态的变化，帮助将基因型与表型联系起来。

DESCRIPTION (provided by applicant): We propose the replacement of a 12-year-old GE (Signa LX) MRI console with a state-of-the-art Varian/Agilent console to support magnetic resonance microscopy for scientists throughout the world. Coupled to an existing 9.4T magnet and a new generation of cryogenic rf probe, this truly unique imaging system will support spatial resolution at the diffusion limit (<10 micrometers). A novel diffusion tensor imaging strategy will provide routine imaging with isotropic spatial resolution <20 micrometers. This resource will support the work of 18 NIH-funded investigators with 27 NIH grants. The system will allow us to increase the throughput for routine magnetic resonance microscopy by more than 3 times; increase the spatial resolution over limited fields by nearly 10 times; and reduce the scan time for diffusion tensor microscopy by at least 4 times. PUBLIC HEALTH RELEVANCE: Sequencing of the human genome has opened an entirely new era of molecular medicine, and one of the most critical issues faced is connecting the vast information in the sequenced human genome to the physical expression-the phenotype. Mouse models are one a critical vehicles to this understanding. Magnetic resonance histology will be used to understand changes in brain morphology of a number of the most critical models, helping connect genotype to phenotype.