BME 265 04 LABORATORY EXERCISE: MAGENTIC RESONANCE MICROSCOPY

内淋巴积水是中阶的扩大， 发生在各种病理条件下，例如梅尼埃病。 对积水的研究具有高度的临床意义，因为它是 人类听力受损的最常见原因。目的 目前的研究是遵循正常的进程 内淋巴积水发生在豚鼠和/或沙鼠身上。 迄今为止，这是不可能的，因为缺乏 用于评估Scala中层尺寸的非侵入性技术。 豚鼠是目前公认的内淋巴积水模型。 它可以通过闭塞内淋巴来人工创造 导管；用八字胡蝙蝠耳蜗体外获得的初步数据 已经表明了这样一项研究的可行性。在正常序列之后 描述了注水的发展过程，然后介绍了各种操作方法， 即不同的药物对动物没有严重的副作用，可以 被用来试图缓解这种情况。因为最终目标是 本研究旨在观察其在体内的进展情况。 内淋巴积水，体型较小的沙鼠可能是动物的选择。

Endolymphatic hydrops is an enlargement of the scala media which occurs in various pathological conditions, e.g. Meniere's disease. Study of hydrops is highly clinically relevant in that it is one of the most common causes of hearing impairment in humans. The purpose of the present research is to follow the normal progression of endolymphatic hydrops as it occurs in the Guinea pig and/or gerbil. To date, this has not been possible because of the lack of a noninvasive technique for assessing the dimensions of the scala media. The guinea pig is currently an accepted model of endolymphatic hydrops and it can be artificially created by occluding the endolymphatic duct; preliminary data obtained with the mustached bat cochlea ex vivo has shown the feasibility of such a study. After the normal sequence of development of hydrops is described, then various manipulations, i.e., different drugs without serious side effects to the animals, can be used to try to alleviate this condition. Since the final goal of this research is to observe the in vivo the progression of endolymphatic hydrops, the smaller gerbil may be the animal of choice.