BME 265 04 LABORATORY EXERCISE: MAGENTIC RESONANCE MICROSCOPY

BME 265 04 实验室练习：磁共振显微镜

• 批准号: 6493759
• 负责人: EDWARD W HSU
• 金额: $ 28.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6493759
• 关键词: Mammalia; biomedical resource; ear; health care; hearing; human tissue; nuclear magnetic resonance spectroscopy

Endolymphatic hydrops is an enlargement of the scala media which occurs in various pathological conditions, e.g. Meniere's disease. Study of hydrops is highly clinically relevant in that it is one of the most common causes of hearing impairment in humans. The purpose of the present research is to follow the normal progression of endolymphatic hydrops as it occurs in the Guinea pig and/or gerbil. To date, this has not been possible because of the lack of a noninvasive technique for assessing the dimensions of the scala media. The guinea pig is currently an accepted model of endolymphatic hydrops and it can be artificially created by occluding the endolymphatic duct; preliminary data obtained with the mustached bat cochlea ex vivo has shown the feasibility of such a study. After the normal sequence of development of hydrops is described, then various manipulations, i.e., different drugs without serious side effects to the animals, can be used to try to alleviate this condition. Since the final goal of this research is to observe the in vivo the progression of endolymphatic hydrops, the smaller gerbil may be the animal of choice.

内淋巴积水是一种中阶扩大， 发生在各种病理条件下，例如梅尼埃病。 水肿的研究具有高度的临床相关性，因为它是 人类听力损伤的最常见原因。 目的 目前的研究是遵循正常的进展， 内淋巴积水，如在豚鼠和/或沙鼠中发生的那样。 到目前为止，这还不可能，因为缺乏一个 评估中阶尺寸的非侵入性技术。 豚鼠是目前公认的内淋巴积水模型 它可以通过阻塞内淋巴管 导管;用离体有胡子蝙蝠耳蜗获得的初步数据 这表明了这项研究的可行性。 在正常序列之后 的发展水肿的描述，然后各种操作， 也就是说，对动物无严重副作用的不同药物， 可以用来缓解这种情况。 自2002年以来， 本研究是为了观察在体内的进展， 内淋巴积水，较小的沙鼠可能是首选的动物。