Mechanistic Understanding leading to Informed Mitigation of Troublesome Dehalogenation in Catalysed Couplings

该项目的目的和目标是：i)确定经常伴随交叉偶联和其他金属催化反应的麻烦的副反应的机理来源；ii)特别是确定芳基脱卤化反应中的形式还原剂“H”的来源，以及还原同质偶合反应中形式氧化物种的来源；iii)区分某些体系中的原脱溴反应和原脱卤化反应，并研究硼酸酯的原脱溴反应；iv)在这种机理见解的基础上，设计减轻或绕过这种过程的方法。

The aims and objectives of the project are to: i) identify the mechanistic origins of troublesome side reactions that are frequently found to accompany cross-coupling and other metal-catalysed reactions; ii) in particular to identify the source of "H" - the formal reductant in aryldehalogenation, and the source of the formal oxidised species in reductive homocoupling coupling; iii) to distinguish protodeboronation from protodehalogenation in some systems, and to study protodeboronation of boronate esters; iv) on the basis of this mechanistic insight, to design means by which to mitigate or bypass such processes.