Chemical approaches to synthetic prototissues

分隔的类细胞实体(原细胞)由广泛的材料组成，作为模拟复杂生物系统和推进未来生命技术的一种手段，在科学界获得了极大的兴趣。特别是，蛋白小体是自组装的膜结合的微尺度结构，已经被证明能够进行生物材料的包裹、选择性通透性、基因导向的蛋白质合成和集体行为。蛋白质体膜的化学编程可以为合成具有前所未有的紧急行为的新的刺激反应原细胞和原组织提供机会，并为新的靶向递送系统提供可能性。为蛋白小体群落提供程序化的化学反应将促进向类生命系统的实用模型发展，并将促进复杂功能微系统和原细胞生态系统的发展。

Compartmentalised cell-like entities (protocells) have been constructed from a wide range of materials and have gained much interest in the scientific community as a means of modelling complex biological systems, and of advancing future living technologies. In particular, proteinosomes are self-assembling membrane-bound microscale constructs which have been shown to be capable of biomaterial encapsulation, selective permeability, gene directed protein synthesis, and collective behaviors. The chemical programming of proteinosome membranes can provide an opportunity for new stimuli-responsive protocells and prototissues to be synthesized with unprecedented emergent behaviors, and the possibility of new targeted delivery systems. Providing proteinosome communities with programmed chemical reactivity will escalate progression towards practical models of life-like systems, and will advance the development of complex functional microsystems and protocellular ecosystems.