NRSA Hepatology Training Grant

NRSA 肝病学培训补助金

• 批准号: 6409418
• 负责人: MARION G PETERS
• 金额: $ 10.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6409418
• 关键词: NRSA; Hepatology; Training; Grant

DESCRIPTION (provided by applicant): Liver disease is among the ten most important causes of death in the United States. However, over the last 10-15 years, there has been a remarkable expansion of basic knowledge in liver biology. This knowledge has led to new modalities for managing the various forms of acute and chronic liver disease. Treatments of viral hepatitis and liver transplantation have captured the headlines, but considerable progress has occurred also in therapy of portal hypertension, gene transfer, and cell transplantation for genetic liver disease, bioartificial liver support for acute liver failure, pathogenesis and therapy of cholestatic diseases, antifibrotic therapy and many others. The extraordinary progress has created a demand for well-trained hepatologists, in particular those who both contribute to current advances in basic knowledge and take disease management to the next level. While progress has been impressive, hepatitis C, hepatocellular carcinoma, and obesity-related liver disease (nonalcoholic steatohepatitis, or NASH) are looming epidemics, for which liver transplantation will not be a realistic solution for all, given the limitation of organ supply. Therefore, we see the training of research hepatologists as a national priority. The Division of Gastroenterology at UCSF has a 30 year history of preeminence in the research and treatment of liver diseases, with an NIH-funded Liver Center since 1975 and, since 1988, a Liver Transplant Program in partnership with the Department of Surgery. Through the Liver Center and joint mentorship of trainees, the Division is closely allied also with the basic sciences at UCSF and the Immunology Program in particular. This application is for funds for a two-year training experience in clinical or basic research, for two individuals annually, in Advanced Hepatology. The program faculty represents the Departments of Immunology/ Microbiology and Pathology as well as Medicine and Surgery. Fellows who select clinical research will receive formal training in clinical/outcomes methodology, with an option to earn an MS or MPH degree. Those in basic or translational laboratory research have a broad array of possibilities with formal courses and a richly supportive environment. Each trainee will have an individual oversight committee to review progress and provide feedback. Graduates of the program will have a productive research program and be fully prepared for a junior faculty position and ideally trained to successfully apply for NIH funding.

描述（由申请人提供）： 肝病是曼联的十个最重要的死亡原因之一 国家。但是，在过去的10 - 15年中，有一个了不起的 扩展肝生物学基础知识。这些知识导致了新的知识 管理各种形式的急性和慢性肝病的方式。 病毒肝炎和肝移植的治疗已捕获 头条新闻，但在门户治疗方面也发生了很大进展 遗传肝的高血压，基因转移和细胞移植 疾病，生物人工肝支持急性肝衰竭，发病机理和 胆汁淤积疾病，抗纤维化疗法的疗法等。这 非凡的进步已经对训练有素的肝病学家提出了需求， 尤其是那些都为基础知识和目前进步做出贡献的人以及 将疾病管理提升到一个新的水平。尽管进步令人印象深刻，但 肝炎，肝细胞癌和与肥胖有关的肝病 （非酒精性脂肪性肝炎或纳什）是迫在眉睫的流行病，肝脏 鉴于限制，移植将不是所有人的现实解决方案 器官供应。因此，我们认为研究肝病学家的培训是 国家优先。 UCSF的胃肠病学系有30年 在肝病研究和治疗中的最高率的历史， 自1975年以来，NIH资助的肝脏中心和自1988年以来 与外科系合作。穿过肝脏中心 学员共同指导，该部门也与 UCSF的基本科学尤其是免疫学计划。这 申请是用于临床或两年培训经验的资金 基础研究，每年在高级肝病学中针对两个人。这 计划教师代表免疫学/微生物学部门 病理以及医学和手术。选择临床研究的研究员 将接受临床/结果方法的正式培训，并有一种选择 获得MS或MPH学位。基本或翻译实验室的人 研究具有正式课程的广泛可能性和丰富的可能性 支持环境。每个学员都会有个人监督 审查进度并提供反馈的委员会。该计划的毕业生 将有一项富有成效的研究计划，并为初中做好充分的准备 教师职位，并接受了理想的培训，可以成功申请NIH资金。