NRSA Hepatology Training Grant

描述(由申请人提供)： 这项申请是为了更新加州大学旧金山分校肝脏生物学和疾病研究培训的资金。理由有两个：(1)该领域发展迅速，目前没有足够数量的训练有素的研究人员，(2)加州大学旧金山分校用于肝脏研究培训的资源和环境非常特殊。该计划以胃肠病学部为基础，为寻求作为学术肝病专家的职业生涯奠定密集基础的受训人员提供两年的支持。它是跨学科的，包括流行病学和生物统计学部门，以及为从事临床和结果研究的人设立的肝脏移植计划，以及为从事实验室研究的人设立的加州大学旧金山分校肝脏中心。导师小组由来自内科、病理学、生物化学和微生物学/免疫学系的13名教员组成。所有人都有肝脏研究的研究计划，培训经验，以及一起工作的记录。该计划由一个指导委员会监督，该委员会负责筛选申请者、提交报价和监测进展。录取申请将每年通过全国广告征集。最大的申请者将是加州大学旧金山分校胃肠病学研究人员(研究密集型)课程的医学博士申请者，但申请过程将向包括S博士在内的其他人开放。成功申请者将拥有出版物形式的成就记录，在许多情况下，还将拥有医学博士和博士学位。只有博士学位的申请者必须有很强的肝脏重点和翻译研究的导向。该计划的培训范围很广，从临床流行病学、遗传学、健康结果和政策，到细胞生物学、器官发生学、免疫学、宿主-病原体相互作用和纤维化/癌症发生。与他们的研究相一致的是，作为加州大学旧金山分校临床研究、生物医学和生物科学研究生课程的一部分，受训者将接受基础和临床科学的正式指导。所有学生都需要一门核心课程，其中包括研究的道德行为和有效的科学交流。这项肝病研究培训的毕业生将准备好担任教职员工级别的职位，并竞争个人的校外资金。

DESCRIPTION (provided by applicant): This application is for renewal funding of research training in liver biology and disease at UCSF. The rationale is two-fold: (1) the field is growing rapidly and currently has insufficient numbers of well-trained investigators, and (2) the resources and environment at UCSF for training in liver research are exceptional. The program, which is based in the Division of Gastroenterology, provides two years of support to trainees who seek an intensive grounding towards a career as academic hepatologists. It is inter-disciplinary, encompassing the Department of Epidemiology and Biostatistics and the Liver Transplant Program for those undertaking clinical and outcomes research, and the UCSF Liver Center for those engaged in laboratory-based research. The mentor group comprises 13 faculty from the Departments of Medicine, Pathology, Biochemistry and Microbiology/Immunology. All have research programs in liver research, experience in training, and a record of working together. The program is overseen by a Steering Committee, which is responsible for screening applicants, tendering offers, and monitoring progress. Applications for admission will be solicited annually by national advertisement. The largest candidate pool will be M.D. applicants to the Investigator (research-intensive) track of the UCSF subspecialty program in Gastroenterology, but the process will be open to others including Ph.D.'s. The successful applicant will have a record of accomplishment in the form of publications and, in many cases, both M.D. and Ph.D. degrees. Applicants with a Ph.D. degree only must have a strong liver focus and orientation to translational research. The range of training within the program is broad, from clinical epidemiology, genetics, health outcomes and policy, to cell biology, organogenesis, immunology, host-pathogen interactions and fibrosis/carcinogenesis. Coincident with their research, trainees are provided formal instruction in basic and clinical sciences as part of the UCSF graduate programs in Clinical Research, Biomedical Sciences and Biological Sciences. A core curriculum encompassing ethical conduct of research and effective scientific communication is required of all students. Graduates of this research training in hepatology will be ready to assume a faculty-level position and to compete for individual extramural funding.