NRSA Hepatology Training Grant

项目摘要/摘要 肝病博士后培训是肝病综合研究的重要组成部分 加州大学旧金山分校的项目。该计划的目的是为学员提供坚实的肝脏生物学和 疾病以及解决新问题和促进新知识的调查技能 肝病。该计划由内科和外科系的12名教员组成； 总的来说，这些人在基础和临床肝病方面提供了平衡的专业知识，并有很强的跟踪能力。 相互协作的记录。一个由6名项目教员组成的小组包括一个指导 负责筛选申请者、审查培训课程和监督 活跃的实习生。该计划的首要任务是培养被加州大学旧金山分校录取为 胃肠病学研究员。该项目的医学博士申请者必须有研究成就的记录 并致力于肝病的独立研究事业。博士申请者主要来自 指导实验室；他们必须表现出类似的学术前景和对翻译肝脏的定位 研究。所有受训人员都将通过一门涵盖肝脏生物学、肝脏相关研究的核心课程。 方法和一般学术技能。然后，他们在个人的指导下接受专门的研究指导 从临床流行病学、健康结局、遗传学到细胞生物学， 免疫学、新陈代谢和纤维化/癌变。强烈推荐额外的重点课程作业 对于所有的实习生；对于那些从事临床研究的人，攻读硕士学位课程是强制性的。 重要的是，培训计划受益于许多机构资源，包括杰出的 基础和临床科学研究生课程以及肝脏中心等研究支持单位 以及临床和翻译科学研究所。在这些单位中，项目教员都是很有影响力的人物， 并相应地指导学员利用这些资源来最大化他们博士后的价值 经验。培训方案的最终目标是提供足够的团体和个人指导 使毕业生能够担任教职员工级别的职位，并成功竞争独立研究 为肝病研究提供资金。

Project Summary/Abstract The Postdoctoral Training Program in Hepatology is an integral part of the comprehensive hepatology research program at UCSF. The purpose of the Program is to provide trainees a solid background in liver biology and disease as well as the investigational skills to address new questions and contribute to new knowledge in hepatology. The Program is staffed by 12 faculty based within the Departments of Medicine and Surgery; collectively these individuals offer balanced expertise in basic and clinical hepatology and have a strong track record of working collaboratively with each other. A subgroup of 6 Program faculty comprise a Steering Committee charged with screening applicants, reviewing the training curriculum and monitoring the progress of active trainees. The top priority of the Program is to train physician-scientists who are admitted to UCSF as Gastroenterology fellows. MD applicants to the Program must have a prior record of research accomplishment and dedication to an independent investigative career in hepatology. PhD applicants are admitted largely from mentor laboratories; they must display similar academic promise and an orientation toward translational liver research. All trainees are placed through a core curriculum covering liver biology, liver-related research methods and general academic skills. They then undergo specialized research instruction under an individual mentor, with choices ranging from clinical epidemiology, health outcomes and genetics to cell biology, immunology, metabolism and fibrosis/carcinogenesis. Additional focused coursework is highly recommended for all trainees; for those pursuing clinical investigation, enrollment in a Master's Degree program is mandatory. Importantly, the Training Program benefits from numerous institutional resources including outstanding graduate programs in basic and clinical sciences as well as research support units such as the Liver Center and the Clinical and Translational Sciences Institute. Program faculty are strong figures in each of these units, and accordingly can guide trainees to utilize these resources to maximize the value of their postdoctoral experience. The ultimate goal of the Training Program is to provide sufficient group and individual mentorship to enable graduates to assume a faculty-level position and compete successfully for independent research funding in hepatology.