The effect of CPAP therapy on memory consolidation and sleep architecture in adults with obstructive sleep apnoea syndrome.

CPAP 治疗对患有阻塞性睡眠呼吸暂停综合征的成人的记忆巩固和睡眠结构的影响。

• 批准号: 1944018
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1944018
• 关键词: effect; CPAP; therapy; memory; consolidation

Obstructive Sleep Apnoea Syndrome (OSAS) affects 2-4% of adults. It is characterised by repeated episodes of upper airway obstruction during sleep, resulting in hypoxia and disturbed sleep. OSAS is strongly linked to obesity, poor mental health and impaired cognitive function, creating a substantial socio-economic burden. Sleep affects the consolidation process that strengthens newly formed memories. A strongly supported view is that newly encountered information is first stored temporarily in the hippocampus, with components of sleep such as "slow oscillations" (<1 Hz) promoting transfer to longer-term neocortical sites. Few studies have examined memory consolidation in patients with OSAS, with no studies incorporating EEG to examine whether impairments in memory consolidation are linked to poor sleep patterns. OSAS is treated with Continuous Positive Airway Pressure (CPAP), requiring patients to wear a face mask during sleep to regulate breathing. Preliminary evidence suggests that CPAP can lead to immediate changes in sleep architecture, including increased slow-wave sleep. However, we do not know if these benefits maintain over time and/or extend to memory consolidation. By addressing these gaps, the proposed research will have clear clinical value and broader benefits for advancing theories of sleep-dependent consolidation across patient and non-patient populations.

阻塞性睡眠呼吸暂停综合征（OSAS）影响2-4%的成年人。其特征是在睡眠期间反复发作上呼吸道阻塞，导致缺氧和睡眠障碍。阻塞性睡眠呼吸暂停综合征与肥胖、精神健康状况差和认知功能受损密切相关，造成了巨大的社会经济负担。睡眠影响巩固过程，巩固新形成的记忆。一个强有力的观点是，新遇到的信息首先暂时存储在海马体中，睡眠的组成部分，如“慢振荡”（<1 Hz），促进转移到长期的新皮层部位。很少有研究对OSAS患者的记忆巩固进行了研究，也没有研究将EEG纳入研究，以检查记忆巩固的障碍是否与睡眠模式不良有关。OSAS采用持续气道正压通气（CPAP）治疗，要求患者在睡眠期间佩戴面罩以调节呼吸。初步证据表明，CPAP可以导致睡眠结构的立即变化，包括增加慢波睡眠。但是，我们不知道这些好处是否会随着时间的推移而保持和/或扩展到内存整合。通过解决这些差距，拟议的研究将具有明确的临床价值和更广泛的利益，以推进患者和非患者人群的睡眠依赖性巩固理论。