BOSTON AREA DIABETES ENDOCRINOLOGY RESEARCH CENTER

总体描述(直接取自应用程序) 波士顿地区糖尿病内分泌研究中心(BADERC)是 以实验室和临床为基础的研究人员，他们的努力 为了解决与病因学有关的许多主要研究问题， 1型和2型糖尿病的发病机制、治疗和治疗 相关的微血管和动脉粥样硬化并发症。中心主任 (约瑟夫·阿夫鲁赫博士)和副主任(乔尔·F·哈伯纳博士和布莱恩博士 Seed)是具有国际地位的高效高级调查人员 信号转导、基因表达、分子生物学和免疫学 是糖尿病研究进展的核心。参与的科学家是 总部设在波士顿地区的大量研究机构，包括 主要的哈佛医学院附属教学医院(马萨诸塞州 总医院、布里格姆妇女医院、贝丝以色列女执事 医学中心)和哈佛附属研究机构(Dana-Farber 癌症研究所，公共卫生学院，谢本斯眼科研究 和波士顿生物医学研究所) 医学中心、新英格兰医学中心和麻省理工学院 理工学院。这些调查人员正在前沿领域工作。 与确定1型和非霍奇金淋巴瘤的发病机制和最佳治疗最相关 2型糖尿病：胰岛素作用和胰岛素的分子遗传学基础 阻力，血管系统和胰岛的生物学，郎格罕， 自身免疫和移植的免疫学基础和最佳治疗方法 排斥反应，以及开发新的血糖监测和治疗方法 控制力。 BADERC为这些科学家提供一系列核心支持服务(分子 生物学、细胞生物学/形态学、转基因、基因敲除、放射免疫分析 和单克隆抗体的产生，荧光激活的细胞分选，以及 代谢生理学)结合了最新的技术进步 提供分子遗传学、细胞生物学和代谢生理学 公认的专家。大多数核心课程在很大程度上侧重于实践培训。 BADERC还将每年主办几次研讨会，重点讨论这些主题 以及一项试点和可行性赠款计划。这是意料之中的 轻松获得高质量、经济高效的支持服务 与教育和试点助学金计划一起，将有助于催化 许多新的合作，并吸引新的人才来糖尿病研究 杰出的科学界。最后，该中心的一个目标是培养 实验室和临床科学家之间最密切的互动， 以确保将研究发现转化为 对糖尿病患者的护理。

OVERALL DESCRIPTION (Taken directly from the application) The Boston Area Diabetes Endocrinology Research Center (BADERC) is a consortium of laboratory-based and clinical investigators whose efforts are directed toward addressing many of the major research questions bearing on the etiology, pathogenesis, treatment and cure of Type 1 and Type 2 diabetes, and their associated microvascular and atherosclerotic complications. The Center Director (Dr. Joseph Avruch) and Associates Directors (Drs. Joel F. Habener and Brian Seed) are highly productive senior investigators of international stature in signal transduction, gene expression, molecular biology, and immunology, topics central to advances in diabetes research. The participating scientists are based at a large number of Boston-area research institutions, including the major Harvard Medical School-affiliated teaching hospitals (the Massachusetts General Hospital, the Brigham and Women's Hospital, the Beth Israel-Deaconess Medical Center) and Harvard-affiliated research institutions (the Dana-Farber Cancer Institute, School of Public Health, the Scheppens Eye Research Institute, and Boston Biomedical Research Institute), the Boston University Medical Center, the New England Medical Center, and the Massachusetts Institute of Technology. These investigators are working at the cutting edge of fields most relevant to defining the pathogenesis and optimal treatment of Type 1 and Type 2 diabetes: the molecular and genetic basis of insulin action and insulin resistance, the biology of the vascular system and islet of Langerhans, the immunologic basis and optimal therapies for autoimmunity and transplant rejection, and the development of new methods for glycemic monitoring and control. The BADERC offers these scientists an array of core support services (Molecular Biology, Cell Biology/Morphology, Transgenics, Gene Knockouts, Radioimmunoassay and Monoclonal Antibody Generation, Fluorescent Activated Cell Sorting, and Metabolic Physiology) that incorporate the latest technical advances in molecular genetics, cell biology, and metabolic physiology provided by acknowledged experts. Most cores are heavily oriented toward hands-on training. The BADERC will also sponsor several symposia each year, focused on the topics outlined above, and a program of pilot and feasibility grants. It is expected that the easy access to cost-effective support services of outstanding quality together with the educational and pilot grants program will serve to catalyze many new collaborations, and attract to diabetes research new talent from this outstanding scientific community. Finally, it is a goal of the center to foster the closest interactions between the laboratory based and clinical scientists, so as to ensure the translation of research discoveries into advances in the care of diabetic patients.