MECHANISMS OF HIV INFECTION IN THE ORAL MUCOSA

口腔粘膜 HIV 感染机制

• 批准号: 6408406
• 负责人: Keith C Norris
• 金额: $ 14.45万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6408406
• 关键词: clinical research; diabetes education; diabetes mellitus; ethnic group; hormone regulation /control mechanism; human subject; hypercholesterolemia; insulin sensitivity /resistance; obesity; urban area

Support is requested to establish a Clinical Center of Research Excellence through the Research Center for Minority Institutions (RCMI) at the Charles R. Drew University of Medicine and Science (Drew). This center, entitled "The Center of Urban Research and Education in Diabetes and Metabolism" (CUREDM), is designed to attract an established research investigator with independent research support and provide research resources for investigators who will study diabetes, insulin resistance states, hypercholesterolemia, obesity, hormonal dysregulation and other metabolic related diseases. These resources will include the development of two core facilities complemented by a developmental project. CUREDM will augment and strengthen Drew's clinical research capabilities through its independent research and its ability to mentor junior investigators. Consistent with the request for this application CUREDM will address health care issues that disproportionately affect the indigenous populations served by the RCMI institutions and are recognized as national health care priorities. The unique patient population at Drew University is comprised of approximately 55 percent Hispanic, 35 percent African Americans, and 10 percent Asian/Pacific Islander who suffer disproportionately from diabetes and metabolic related disorders. Over the last 4 years Drew has experienced a progressive enhancement in the clinical research infrastructure and an increasing number of investigators with research interest and activity in diabetes and metabolic related diseases. This creates an appropriate environment of professional interaction and growth that will facilitate the recruitment of a highly qualified investigator to direct CUREDM. Thus, Drew is an ideal location for the establishment of CUREDM. Although there is a particularly high prevalence of diabetes and metabolic disorders in underserved populations, these disorders are pervasive in our society and information gained from CUREDM is likely to yield important contributions toward improving health care for the nation.

请求支持通过查尔斯·R·德鲁医学与科学大学（德鲁）的少数民族机构研究中心（RCMI）建立卓越临床研究中心。 该中心名为“糖尿病与代谢城市研究与教育中心”（CUREDM），旨在吸引具有独立研究支持的知名研究人员，并为研究糖尿病、胰岛素抵抗状态、高胆固醇血症、肥胖、激素失调和其他代谢相关疾病的研究人员提供研究资源。 这些资源将包括两个核心设施的开发以及一个开发项目的补充。 CUREDM 将通过其独立研究和指导初级研究人员的能力来增强和加强 Drew 的临床研究能力。 根据本申请的要求，CUREDM 将解决对 RCMI 机构服务的土著居民产生不成比例影响的医疗保健问题，并被视为国家医疗保健优先事项。 德鲁大学独特的患者群体由大约 55% 的西班牙裔、35% 的非裔美国人和 10% 的亚裔/太平洋岛民组成，他们患有糖尿病和代谢相关疾病的比例不成比例。 在过去的 4 年里，德鲁经历了临床研究基础设施的逐步增强，以及越来越多的研究人员对糖尿病和代谢相关疾病的研究兴趣和活动。 这创造了一个适当的专业互动和成长环境，将有助于招募高素质的研究者来指导 CUREDM。 因此，德鲁是建立 CUREDM 的理想地点。 尽管在服务不足的人群中，糖尿病和代谢性疾病的患病率特别高，但这些疾病在我们的社会中普遍存在，从 CUREDM 获得的信息可能会对改善国家的医疗保健做出重要贡献。