Elucidating crosstalk between RhoGTPases and polarity proteins: the interface between morphology, immune function and cancer.

癌症和自身免疫方面的重大突破需要了解控制细胞行为的分子基础。我们现在知道了关键的分子参与者，但仍然需要确定它们在细胞内如何相互作用，以开发最佳的治疗和诊断方法。最近的突破使我们能够“观察”细胞内的分子相互作用。我们将使用这些方法来确定免疫细胞和癌细胞中的关键分子开关是如何调节的。

Major breakthroughs in cancer and autoimmunity require understanding the molecular basis of by which cell behaviour is controlled. We now know the key molecular players, but still need to determine how they interact within the cell to develop the best treatments and diagnostics. Recent breakthroughs now enable us to “watch” molecular interactions within the cell. We will use these approaches to determine how a key molecular switch is regulated in immune cells and cancer cells.