Elucidating crosstalk between RhoGTPases and polarity proteins: the interface between morphology, immune function and cancer.

阐明 RhoGTP 酶和极性蛋白之间的串扰：形态、免疫功能和癌症之间的界面。

• 批准号: nhmrc : 1061647
• 负责人: A/Pr Andrew Clayton
• 金额: $ 41.85万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-crosstalk-rhogtpases-function-cancer/454915
• 关键词: Elucidating; crosstalk; between; RhoGTPases; polarity

Major breakthroughs in cancer and autoimmunity require understanding the molecular basis of by which cell behaviour is controlled. We now know the key molecular players, but still need to determine how they interact within the cell to develop the best treatments and diagnostics. Recent breakthroughs now enable us to “watch” molecular interactions within the cell. We will use these approaches to determine how a key molecular switch is regulated in immune cells and cancer cells.

癌症和自身免疫的重大突破需要了解细胞行为控制的分子基础。我们现在知道了关键的分子参与者，但仍然需要确定它们如何在细胞内相互作用，以开发最佳的治疗和诊断方法。最近的突破使我们能够“观察”细胞内的分子相互作用。我们将使用这些方法来确定一个关键的分子开关是如何在免疫细胞和癌细胞中调节的。