CHRONIC RECORDING USING SILICON MICROPROBES: CHRONIC IMPLANTS & MOTOR CORTEX

使用硅微探针进行慢性记录：慢性植入物

• 批准号: 6505240
• 负责人: JOHN C MIDDLEBROOKS
• 金额: $ 20.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6505240
• 关键词: Mammalia; animal tissue; bioengineering /biomedical engineering; biomaterials; biomedical equipment development; biomedical resource; medical rehabilitation related tag; nervous system; prosthesis; technology /technique

The most common application for which probes are requested is that of cortical recording. Although many different cortical areas are being explored (motor, visual, auditory), the preparations share similarities and problems which make collaborations with the Center and between external investigators increasingly important. Along with providing standard probes for acute cortical recording, the Center is working with collaborators (both institutional and corporate) to come up with probes, connectors, chamber designs and preparations for long-term implants. The challenges encountered in most of these preparations include placement of multiple devices into a single cranial chamber; maintaining positional stability of the probes; and inhibition of tissue encapsulation around the cable or 3-D platform due to healing of the cranium and dura. Several of the above collaborators continue to work on cranial chambers designed to hold several integrated cable/probes (either 2-D or 3-D) which protrude from the chamber edge into the cortical area. Some of the fixtures include a removable cap for access to the implants for inspection, cleaning and/or probe replacement. In the area of probe stability, collaborators are working with adhesives such as cyanoacrylate and fibrin glue to anchor the probes to the brain's surface. The University of Michigan Department of Materials Science and Engineering is also developing biological "glues" as well as materials which will inhibit tissue adhesion to apply to probe substrates. Surgical methods such as tenting of the dura over the probe insertions are being explored as well.

要求使用探头的最常见应用是： 大脑皮层记录 尽管许多不同的皮层区域 正在探索（运动，视觉，听觉），准备分享 与中心合作的相似之处和问题 和外部调查人员之间的联系越来越重要。 沿着 该中心为急性皮层记录提供标准探头， 与合作者（机构和企业）合作， 提供探针、连接器、腔室设计和准备， 长期植入 在大多数情况下遇到的挑战 准备工作包括将多个设备放置到单个 保持探头的位置稳定性;以及 抑制线缆或3-D平台周围的组织包囊 因为颅骨和硬脑膜的愈合 若干上述 合作者继续致力于设计用于容纳 多个集成电缆/探头（2-D或3-D）， 从腔室边缘进入皮质区 的一些灯具 包括用于接近植入物进行检查的可移除帽， 清洁和/或更换探头。 在探针稳定性方面， 合作者正在研究粘合剂，如氰基丙烯酸酯和 纤维蛋白胶将探针锚在大脑表面 的 密歇根大学材料科学与工程系 同时也在开发生物“胶”和材料， 抑制组织粘附以施加到探针基底。 手术 例如在探针插入物上隆起硬脑膜的方法， 也在探索中。