Alcoholism: Epidemiologic High Risk Family Study

描述：（由申请人提供）这是R 0 I的重新提交 在流行病学研究中嵌套高风险遗传/家族研究的应用程序 框架，代表了酒精流行病学研究的新范式 依赖（AD）。特别是，它对非洲裔美国人（Af-A）的过度抽样 家庭将允许测试青少年和年轻人的长期模型， 成人酒精参与基于多数（主要）（主要） 高加索）青年。除了对Af-A家庭的过度抽样外， 优点是：从代表性样本中确定家庭; AD高危家庭抽样;多个家庭的直接评估 成员;对后代进行为期2年的随访;收集DNA以确定父子关系 确认.家庭是通过个人的出生记录确定的， 出生年份队列的基线年龄为13、15、17和19岁， 有2个或更多后代的家庭样本，并通过电话进行筛选， 确定潜在的高风险家庭。对于筛查阳性的家庭（即， 指数病例的父亲被报告为过度饮酒者）， 那些筛查阴性的，亲生母亲和父亲（或最佳线人） ”（《礼记》）“以其人之道还治其人之身，以其人之道还治其人之身。 其他精神病理学，以及索引病例的精神病理学史 和1或2个13-31岁的兄弟姐妹。在样品中加入大量酒精 父亲，男性有2个或更多的D Wis（“经常性醉酒驾驶- RDD”）确定 从州驾驶记录数据将与出生记录数据匹配， 选择其中一名在指定出生年份出生的子女作为索引 孩子，这些家庭包括在协议中。索引病例和1或2例 来自父亲符合DSM-IV AD终身标准的家庭的兄弟姐妹， 自己的报告或2份举报人报告（“高风险”：150份Afr-Af-A，75份多数（主要）） 家庭），那些来自父亲不符合AD标准的家庭（“对照 “：150 Af-A，75 Maj），而来自RDD家庭的人（150 Af-A，150 Maj）将 邀请进行电话诊断访谈和问卷填写，以及 两年后，孩子们重新接受了采访。将持续分析数据 我们的研究小组使用更专业的双胞胎家庭设计进行了研究。数据 将用于测试酒精和其他物质参与的2个模型， 特别是当这些与Af-A家庭有关时;以及关于 兄弟姐妹对酒精和其他物质参与和问题的影响 传统的父母一个孩子甚至专门的双胞胎家庭研究 以有限的方式进行了测试;以及横截面和纵向关联 父母教养方式、父亲AD、其他父母合并症、自身合并症， 气质，创伤事件和发展转变（学校，工作， 婚姻）与：后代酒精，尼古丁和其他药物的使用，问题和 紊乱

DESCRIPTION: (provided by applicant) This is a resubmission of an R0l application that nests a high risk genetic/family study within an epidemiologic framework, representing a novel paradigm for epidemiologic research on alcohol dependence (AD). In particular, its over sampling of African-American (Af-A) families will permit testing of long-standing models of adolescent and young adult alcohol involvement that have been based on Majority (Maj) (primarily Caucasian) youth. In addition to its over sample of Af-A families, other advantages are: ascertainment of families from a representative sample; over sampling of families at high risk of AD; direct assessments of multiple family members; 2-year follow-up of offspring; and collection of DNA for paternity confirmation. Families are ascertained thru birth records of individuals from birth year cohorts to be aged of 13,15,17 and 19 at baseline, with an over sample of families with 2 or more offspring, and screened by telephone to identify potentially high risk families. For families screening positive (i.e., index case's father is reported as an excessive drinker), and a sub-sample of those screening negative, biological mothers and fathers (or best informant thereof) will be interviewed by telephone about own, and co-parent's AD and other psychopathology, as well as history of psychopathology in the index case and 1 or 2 siblings aged 13-31. To enrich the sample with severely alcoholic fathers, men with 2 or more D Wis ("Recurrent Drunk Driving - RDD) identified from state driving record data will be matched to birth record data in order to select one of their children born in the specified birth years as an index child, and these families included in the protocol. Index cases and 1 or 2 siblings from families where fathers meet lifetime criteria for DSM-IV AD, by own report or 2 informant reports ("high risk": 150 Afr-Af-A, 75 Majority (Maj) families), those from families where fathers did not meet AD criteria ("control ": 150 Af-A, 75 Maj), and those from RDD families (150 Af-A, 150 Maj) will be invited for telephone diagnostic interview and questionnaire completion, and offspring re-interviewed 2 years later. Data will be analyzed with ongoing studies in our research group using more specialized twin-family designs. Data will be used to test 2 models of alcohol and other substance involvement, particularly as these relate to Af-A families; as well as hypotheses about sibling influences on alcohol and other substance involvement and problems which conventional parent-one child and even specialized twin-family studies have tested in a limited way; and cross sectional and longitudinal associations of: parenting style, paternal AD, other parental comorbidity, own comorbidity, temperament, traumatic events, and developmental transitions (school, work, marriage) with: offspring alcohol, nicotine and other drug use, problems and disorders.