Elucidating the genetics and biology of spontaneous coronary artery dissection (SCAD): a life-threatening heart disease of women

阐明自发性冠状动脉夹层（SCAD）的遗传学和生物学：一种危及女性生命的心脏病

• 批准号: nhmrc : GNT1161200
• 金额: $ 136.87万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-genetics-biology-disease-women/1379162
• 关键词: Elucidating; genetics; biology; spontaneous; coronary

Spontaneous coronary artery dissection (SCAD) is a tear in an artery that supplies blood to the heart. It is a potentially fatal problem that presents as a heart attack or sudden death, affecting relatively young (45-52 yr) women (95% of cases) with few risk factors. The cause of SCAD likely has a genetic basis that enhances susceptibility to vessel rupture. Here we propose to investigate the genetics, cell biology and vascular reactivity of SCAD patients to better understand and treat SCAD.

自发性冠状动脉夹层(SCAD)是供应心脏血液的动脉的撕裂。这是一个潜在的致命问题，表现为心脏病发作或猝死，影响相对年轻(45-52岁)的妇女(95%的病例)，几乎没有危险因素。SCAD的病因可能有一个遗传基础，这增加了血管破裂的易感性。在这里，我们建议对SCAD患者的遗传学、细胞生物学和血管反应性进行研究，以更好地了解和治疗SCAD。