Elucidating the genetics and biology of spontaneous coronary artery dissection (SCAD): a life-threatening heart disease of women

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Spontaneous coronary artery dissection (SCAD) is a tear in an artery that supplies blood to the heart. It is a potentially fatal problem that presents as a heart attack or sudden death, affecting relatively young (45-52 yr) women (95% of cases) with few risk factors. The cause of SCAD likely has a genetic basis that enhances susceptibility to vessel rupture. Here we propose to investigate the genetics, cell biology and vascular reactivity of SCAD patients to better understand and treat SCAD.