Elucidating unique molecular mechanisms involved in HIV-1 subtype C pathogenicity

阐明 HIV-1 C 亚型致病性的独特分子机制

• 批准号: nhmrc : 1022066
• 负责人: A/Pr Paul Ramsland
• 金额: $ 47.41万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/elucidating-unique-molecular-c-pathogenicity/110161
• 关键词: Elucidating; unique; molecular; mechanisms; involved

Most people infected with human immunodeficiency virus (HIV) have subtype C virus (C-HIV) and live in Southern Africa and Central Asia. These regions are where the HIV pandemic is at its worst. However, we know very little about C-HIV. We have evidence that C-HIV evolves differently compared to other HIV-1 subtypes, which impacts the way it leads to AIDS. This project aims to characterise these unique molecular mechanisms, which may lead to vaccines and drugs that are optimised for C-HIV.

大多数感染人类免疫缺陷病毒（HIV）的人都有C亚型病毒（C-HIV），生活在南部非洲和中亚。这些地区是艾滋病毒流行病最严重的地区。然而，我们对C-HIV知之甚少。我们有证据表明，与其他HIV-1亚型相比，C-HIV的进化方式不同，这影响了它导致艾滋病的方式。该项目旨在研究这些独特的分子机制，这可能导致针对C-HIV优化的疫苗和药物。