Molecular imaging and therapy of solid tumours

实体瘤的分子成像和治疗

• 批准号: nhmrc : 1030469
• 负责人: A/Pr Paul Ramsland
• 金额: $ 53.81万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-imaging-therapy-solid-tumours/110757
• 关键词: Molecular; imaging; therapy; solid; tumours

Use of antibodies for cancer therapy, where a protein is made in the laboratory to recognize and act on cancer cells that have a target antigen, has emerged as an important therapeutic area in oncology. The lewis-y (Ley) antigen is found on more than 70% of epithelial cancers and the A33 antigen is found on colon cancers. We have developed antibodies against Ley (hu3S193) and A33 (huA33) which can target cancer cells. We aim to develop optimal cancer cell killing by our antibodies.

使用抗体进行癌症治疗，其中在实验室中制备蛋白质以识别并作用于具有靶抗原的癌细胞，已成为肿瘤学中的重要治疗领域。Lewis-γ（Ley）抗原在70%以上的上皮癌中发现，A33抗原在结肠癌中发现。我们已经开发了针对Ley（hu3S193）和A33（huA33）的抗体，其可以靶向癌细胞。我们的目标是通过我们的抗体开发最佳的癌细胞杀伤。