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Structural investigations of bacterial evasion of IgA mucosal and systemic immunity

Structural investigations of bacterial evasion of IgA mucosal and systemic immunity
细菌逃避 IgA 粘膜和全身免疫的结构研究
批准号:
nhmrc : 543317
负责人:
A/Pr Paul Ramsland
金额:
$32.59万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2013-12-31

项目摘要

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中文摘要
翻译
鼻、喉和皮肤感染通常是由链球菌和葡萄球菌引起的,称为链球菌性咽喉炎和金黄色葡萄球菌。感染可能危及新生儿、老年人或免疫系统较弱的人的生命。这些细菌使蛋白质结合并抑制免疫蛋白质。我们的研究检查了细菌与一种关键免疫系统蛋白(一种称为伊加的抗体)相互作用的结构基础,并可能导致新的预防和治疗策略。
英文摘要
Nose, throat and skin infections are often caused by streptococcal and staphylococcal bacteria, known as Strep Throat and Golden Staph. Infections can be life-threatening in newborns, the elderly or individuals with weak immune systems. These bacteria make proteins bind and inactivate immune proteins. Our research examines the structural basis for bacterial interactions with a key immune system protein (an antibody called IgA) and may lead to new prevention and treatment strategies.
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Understanding HIV Resistance to Entry Inhibitors to Advance the Development of Novel Antivirals
  • 批准号:
    nhmrc : GNT1126740
  • 项目类别:
    Project Grants
  • 资助金额:
    $87.76万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Paul Ramsland
  • 依托单位:
Understanding HIV Resistance to Entry Inhibitors to Advance the Development of Novel Antivirals
  • 批准号:
    nhmrc : 1126740
  • 项目类别:
    Project Grants
  • 资助金额:
    $59.92万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Paul Ramsland
  • 依托单位:
Envelope Glycoprotein Determinants of HIV-1 Subtype C Tropism and Pathogenicity
  • 批准号:
    nhmrc : 1086178
  • 项目类别:
    Project Grants
  • 资助金额:
    $43.86万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Paul Ramsland
  • 依托单位:
Envelope Glycoprotein Determinants of HIV-1 Subtype C Tropism and Pathogenicity
  • 批准号:
    nhmrc : GNT1086178
  • 项目类别:
    Project Grants
  • 资助金额:
    $63.68万
  • 财政年份:
    2015
  • 负责人:
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  • 依托单位:
海外基金