Structural investigations of bacterial evasion of IgA mucosal and systemic immunity

细菌逃避 IgA 粘膜和全身免疫的结构研究

• 批准号: nhmrc : 543317
• 负责人: A/Pr Paul Ramsland
• 金额: $ 32.59万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-investigations-bacterial-systemic-immunity/100901
• 关键词: Structural; investigations; bacterial; evasion; IgA

Nose, throat and skin infections are often caused by streptococcal and staphylococcal bacteria, known as Strep Throat and Golden Staph. Infections can be life-threatening in newborns, the elderly or individuals with weak immune systems. These bacteria make proteins bind and inactivate immune proteins. Our research examines the structural basis for bacterial interactions with a key immune system protein (an antibody called IgA) and may lead to new prevention and treatment strategies.

鼻、喉和皮肤感染通常是由链球菌和葡萄球菌引起的，称为链球菌性咽喉炎和金黄色葡萄球菌。对于新生儿、老年人或免疫系统较弱的人来说，感染可能危及生命。这些细菌使蛋白质结合并抑制免疫蛋白质。我们的研究检查了细菌与一种关键免疫系统蛋白（一种称为伊加的抗体）相互作用的结构基础，并可能导致新的预防和治疗策略。