ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATION

巴西人口的抗氧化剂营养素

• 批准号: 6513545
• 负责人: Anna R. Giuliano
• 金额: $ 38.61万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-16 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6513545
• 关键词: Brazil; South American; blood chemistry; cancer risk; carotenoids; cervix neoplasms; clinical research; female; human papillomavirus; human subject; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; tocopherols; virus load; virus related neoplasm /cancer; women's health

DESCRIPTION (Adapted from the Applicant's Abstract): Epidemiologic research conducted over the past couple of decades has shown that infection with the human papilloma virus (HPV) is a cause of most cases of cervical cancer. Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased risk of developing CIN compared with women transiently infected. In addition, persistently HPV positive women appear to be four times more likely to have persistent cervical lesions. Although HPV infection is a cause of cervical cancer, it may be an insufficient cause requiring the presence of other factors for the infection to progress to a significant cervical lesion. Nutritional status may be an important cofactor affecting both HPV persistence and progression of persistent HPV infection to CIN. However, the association between nutritional status and cervical carcinogenesis has not been adequately tested. The overall goal of this application is to determine, using prospectively collected HPV and cytology data, the association between serum carotenoid and tocopherol status and cervical carcinogenesis among a cohort of high risk study participants in the Brazilian HPV Natural History Cohort (RO1 CA70269). This project will provide the first prospective analysis of serum carotenoid and tocopherol concentrations and risk for persistent HPV infection; it will be based on sensitive and specific methods for assessing type of HPV infection over a 12 month period, and evaluate subsequent 5 year risk of progression to CIN. This proposed study is unique in that if focuses on early events in cervical carcinogenesis: HPV infection, HPV persistence, and progression to CIN. It is cost-effective, utilizing previously collected serum samples and questionnaire data. The study utilizes state of the art methods for determining both PV status and serum carotenoid and tocopherol status. Furthermore, it incorporates multiple measurements of both HPV status and serum nutrient concentrations minimizing the probability that measurement imprecision resulting from temporal fluctuations will obscure the true association between nutrients status, and HPV persistence and risk of CIN. Results from this study will efficiently further our understanding of the role of antioxidant nutrients and cervical carcinogens.

描述（改编自申请人的摘要）：流行病学研究 过去几十年的研究表明，感染 人乳头瘤病毒 (HPV) 是大多数宫颈癌病例的病因。 前瞻性研究表明，感染 HPV 的女性更有可能 发展为宫颈上皮内瘤变（CIN），并且那些患有 持续致癌型 HPV 感染的风险显着增加 与短暂感染的女性相比，发生 CIN 的几率更高。此外， HPV 持续呈阳性的女性罹患 HPV 的可能性似乎是其他女性的四倍 持续性宫颈病变。 虽然 HPV 感染是宫颈癌的一个原因，但它可能还不足以 需要存在其他因素才能使感染进展到的原因 明显的宫颈病变。营养状况可能是一个重要的辅助因素 影响 HPV 持续性和持续性 HPV 感染的进展 CIN。然而，营养状况与宫颈癌之间的关系 致癌作用尚未经过充分测试。 该应用程序的总体目标是确定、前瞻性地使用 收集了 HPV 和细胞学数据，血清类胡萝卜素与 一组高风险研究中的生育酚状况和宫颈癌发生 巴西 HPV 自然历史队列 (RO1 CA70269) 的参与者。这 项目将首次对血清类胡萝卜素进行前瞻性分析 生育酚浓度和持续 HPV 感染的风险；这将是 基于评估 HPV 感染类型的敏感且具体的方法 12 个月内，并评估随后 5 年进展为 CIN。这项拟议的研究的独特之处在于，如果重点关注早期事件 宫颈癌发生：HPV 感染、HPV 持续存在以及进展为 CIN。它具有成本效益，利用以前收集的血清样本和 问卷数据。该研究利用最先进的方法来确定 PV 状态以及血清类胡萝卜素和生育酚状态。此外，它 包含 HPV 状态和血清营养的多项测量 浓度最大限度地减少测量不精确的可能性 时间波动产生的结果将掩盖之间的真实关联 营养状况、HPV 持续性和 CIN 风险。这项研究的结果 将有效地加深我们对抗氧化营养素作用的理解 和宫颈癌物质。