d-Amino Acids and d-Foldamers : New helical constructs for catalysis

d-氨基酸和 d-Foldamers：用于催化的新型螺旋结构

• 批准号: 1951102
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1951102
• 关键词: Amino; Acids; Foldamers; New; helical

The synthesis of 3 main delta-amino acid target molecules, and their related analogous, leading to the generation of a library of diverse monomers. From this, simple a,d- peptide sequences will then be synthesised, with a view to eventually synthesising rationally designed, novel aldolase peptide sequences. A variety of conventional organic synthetic techniques are to be used in the synthesis of the amino acid target molecules, with organocatalysis being a common theme. Solution phase synthesis used in order to synthesis the desired peptide sequences. Use of NMR, CD and X-ray crystallography to gain structural information for the peptides.

3 个主要 δ-氨基酸目标分子及其相关类似物的合成，导致生成不同单体库。 From this, simple a,d- peptide sequences will then be synthesised, with a view to eventually synthesising rationally designed, novel aldolase peptide sequences.多种常规有机合成技术可用于氨基酸目标分子的合成，其中有机催化是常见主题。使用溶液相合成来合成所需的肽序列。使用 NMR、CD 和 X 射线晶体学来获取肽的结构信息。

项目成果

Syntheses and applications of enantiopure d-amino acids and their precursors

对映体纯d-氨基酸及其前体的合成与应用

• DOI: 10.1016/j.tet.2018.05.034
• 发表时间: 2018
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Stendall R