SUBSTANCE DEPENDENT TEENS--IMPACT OF TREATING DEPRESSION

物质依赖青少年——治疗抑郁症的影响

• 批准号: 6653679
• 负责人: Paula DeGraffenreid Riggs
• 金额: $ 6.2万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653679
• 关键词: adolescence (12-20); behavioral /social science research tag; clinical research; clinical trials; cognitive behavior therapy; combination therapy; comorbidity; conduct disorder; fluoxetine; human subject; human therapy evaluation; major depression; mental disorder chemotherapy; substance abuse related disorder; therapy compliance

DESCRIPTION: (Applicant's Abstract) Adolescents with substance use disorders (SUD) and conduct disorder (CD) have high rates of comorbid depression. Despite the high prevalence of depression in such youth, little is known about effective treatment of such depressions. Moreover, the effects of treating depression on substance use and other problem behaviors in such youth are not known. Only serotonergic agents, fluoxetine (FLX) and paroxetine, with most support for FLX, have empirical support in the treatment of depression in adolescents without serious comorbidity. It is not known whether FLX (or paroxetine) are effective in treating the depressions of adolescents with SUD and CD. The proposed study is a randomized, placebo-controlled trial comparing placebo to fluoxetine for major depressive disorder (MDD) in 120 adolescents with SUD and CD. Adolescents with DSM-1V SUD, CD, and MDD assessed both clinically and with structured assessment instruments, will be randomized to one of these two treatment cells for 16 weeks. All subjects will also receive standardized, manual-driven cognitive behavior treatment for adolescent SUD for the duration of the trial as the background "treatment as usual" Medication compliance will be electronically monitored. Adverse side effects will be monitored weekly. The specific aims of this study are to test the following hypotheses: 1. Fidoxeline + CBT will be more effective in treating unipolar depression in adolescents with SUD and CD than placebo + CBT. 2. The treatment of depression with RX + CBT, in depressed adolescents with SUD and CD will be more effective than placebo + CBT in reducing substance use and improving conduct symptoms. 3. The treatment of depression with RX will result in greater retention in, and compliance with substance treatment (CBT) and reduction in both substance use and conduct problems than treatment with placebo. This research will contribute important knowledge regarding effective treatment of depression in conduct-disordered adolescents with SUD and provide information about the effects of treating depression on substance and other behavioral outcomes as well.

描述：(申请人摘要) 患有物质使用障碍(SUD)和品行障碍(CD)的青少年 患上抑郁症的比率很高。尽管#年抑郁症患病率很高 对于这样的年轻人，人们对这种抑郁症的有效治疗知之甚少。 此外，治疗抑郁症对物质使用和其他问题的影响 这些年轻人的行为并不为人所知。只有5-羟色胺能药，氟西汀 氟西汀和帕罗西汀对氟西汀的支持最多，在 无严重共病的青少年抑郁症的治疗。它不是 已知氟西汀(或帕罗西汀)是否有效治疗抑郁症 患有SUD和CD的青少年。拟议的研究是一项随机的、 安慰剂对照试验比较安慰剂和氟西汀治疗重度抑郁症 120例SUD和CD青少年的精神障碍(MDD)患有DSM-1V SUD的青少年， CD和MDD既有临床评估，也有结构化评估 仪器，将被随机分配到这两个处理单元中的一个，用于16 几周。所有受试者也将接受标准化的、手动驱动的认知 在试验期间对青少年SUD的行为治疗 背景“照常治疗”服药依从性将是电子化的 被监视着。每周都会监测不良反应。的具体目标 本研究旨在验证以下假设：1.非多昔林+CBT SUD和CD对青少年单相抑郁的更有效治疗 而不是安慰剂+CBT。2.RX+CBT治疗抑郁症 患有SUD和CD的青少年在以下方面将比安慰剂+CBT更有效 减少药物使用，改善行为症状。3.治疗 使用RX的抑郁将导致更大的保留和遵从性 物质治疗(CBT)和减少物质使用和行为 比用安慰剂治疗更有问题。这项研究将对未来的发展做出重要贡献。 关于有效治疗品行障碍中抑郁的知识 并提供有关治疗效果的信息。 对物质和其他行为结果的抑郁。