SUBSTANCE DEPENDENT TEENS--IMPACT OF TREATING DEPRESSION
物质依赖青少年——治疗抑郁症的影响
基本信息
- 批准号:6646416
- 负责人:
- 金额:$ 65.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-09-30 至 2005-07-31
- 项目状态:已结题
- 来源:
- 关键词:adolescence (12-20) behavioral /social science research tag clinical research clinical trials cognitive behavior therapy combination therapy comorbidity conduct disorder fluoxetine human subject human therapy evaluation major depression mental disorder chemotherapy substance abuse related disorder therapy compliance
项目摘要
DESCRIPTION: (Applicant's Abstract)
Adolescents with substance use disorders (SUD) and conduct disorder (CD) have
high rates of comorbid depression. Despite the high prevalence of depression in
such youth, little is known about effective treatment of such depressions.
Moreover, the effects of treating depression on substance use and other problem
behaviors in such youth are not known. Only serotonergic agents, fluoxetine
(FLX) and paroxetine, with most support for FLX, have empirical support in the
treatment of depression in adolescents without serious comorbidity. It is not
known whether FLX (or paroxetine) are effective in treating the depressions of
adolescents with SUD and CD. The proposed study is a randomized,
placebo-controlled trial comparing placebo to fluoxetine for major depressive
disorder (MDD) in 120 adolescents with SUD and CD. Adolescents with DSM-1V SUD,
CD, and MDD assessed both clinically and with structured assessment
instruments, will be randomized to one of these two treatment cells for 16
weeks. All subjects will also receive standardized, manual-driven cognitive
behavior treatment for adolescent SUD for the duration of the trial as the
background "treatment as usual" Medication compliance will be electronically
monitored. Adverse side effects will be monitored weekly. The specific aims of
this study are to test the following hypotheses: 1. Fidoxeline + CBT will be
more effective in treating unipolar depression in adolescents with SUD and CD
than placebo + CBT. 2. The treatment of depression with RX + CBT, in depressed
adolescents with SUD and CD will be more effective than placebo + CBT in
reducing substance use and improving conduct symptoms. 3. The treatment of
depression with RX will result in greater retention in, and compliance with
substance treatment (CBT) and reduction in both substance use and conduct
problems than treatment with placebo. This research will contribute important
knowledge regarding effective treatment of depression in conduct-disordered
adolescents with SUD and provide information about the effects of treating
depression on substance and other behavioral outcomes as well.
描述:(申请人摘要)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paula DeGraffenreid Riggs其他文献
Paula DeGraffenreid Riggs的其他文献
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{{ truncateString('Paula DeGraffenreid Riggs', 18)}}的其他基金
Bupropion for ADHD in Adolescents with Substance Use Disorders
安非他酮治疗患有药物使用障碍的青少年多动症
- 批准号:
8322985 - 财政年份:2008
- 资助金额:
$ 65.75万 - 项目类别:
Bupropion for ADHD in Adolescents with Substance Use Disorders
安非他酮治疗患有药物使用障碍的青少年多动症
- 批准号:
7840535 - 财政年份:2008
- 资助金额:
$ 65.75万 - 项目类别:
Bupropion for ADHD in Adolescents with Substance Use Disorders
安非他酮治疗患有药物使用障碍的青少年多动症
- 批准号:
7367685 - 财政年份:2008
- 资助金额:
$ 65.75万 - 项目类别:
Bupropion for ADHD in Adolescents with Substance Use Disorders
安非他酮治疗患有药物使用障碍的青少年多动症
- 批准号:
8278586 - 财政年份:2008
- 资助金额:
$ 65.75万 - 项目类别:
Bupropion for ADHD in Adolescents with Substance Use Disorders
安非他酮治疗患有药物使用障碍的青少年多动症
- 批准号:
8077427 - 财政年份:2008
- 资助金额:
$ 65.75万 - 项目类别:
Bupropion for ADHD in Adolescents with Substance Use Disorders
安非他酮治疗患有药物使用障碍的青少年多动症
- 批准号:
7675467 - 财政年份:2008
- 资助金额:
$ 65.75万 - 项目类别:
SUBSTANCE DEPENDENT TEENS--IMPACT OF TREATING DEPRESSION
物质依赖青少年——治疗抑郁症的影响
- 批准号:
6653679 - 财政年份:2000
- 资助金额:
$ 65.75万 - 项目类别:














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