NIDA STRENGTHENING WASHINGTON, DC FAMILIES GRANT

描述：（申请人摘要） 这项为期五年的研究的目标是提供以下方面的新知识：1） 内城区非裔美国人和白人吸毒和滥用的原因 青少年，2) 最具成本效益和成本效益 以家庭为中心的预防干预措施。 本课题的研究目的 涉及华盛顿特区 800 多个高危地区的随机临床试验 7 至 11 岁家庭的 16 周强化课程 家庭计划 (SFP) 的目的是： 1) 测试不同功效 SFP的三大组成部分——家长培训（PT）、儿童技能 培训（CT）和家庭技能培训（FT）与最小接触相比 采用 2 x 4 对前体和物质使用/滥用进行控制 (MT) 实验设计； 2）估计成本效益和成本效益 400 个非洲裔美国家庭和 400 个白人家庭的 SFP 组件 家庭； 3）根据经验测试几种相互竞争的病因学和 干预设计背后的药物使用/滥用干预理论 通过分析 1,600 名 12 至 19 岁青少年的调查研究数据， 使用结构方程模型、中介方法对 800 个家庭进行干预 分析、分层线性模型、潜在增长模型，以及 事务建模（交叉滞后的 SEM、人工智能和 神经网络模拟）针对性别、种族和其他亚组。 的 组件设计的基本原理是存在一个主要问题 关于针对高危人群的仅限儿童的干预措施的有效性 孩子们在一起以及与家人一起工作的额外好处 与仅进行家长培训相比。 展示的重要性 让父母参与并与家人一起工作将非常有价值 为预防提供者提供的信息。 额外的协变量结果 将进行分析以回答有关的实际问题 四种干预措施对不同客户亚组的功效。 一个 强大的流程评估，包括管理信息系统（MIS） 由马里兰大学研究人员进行，将记录实施情况 过程并提供反馈以提高实施保真度。 附加 卫生服务分目标问题将通过分析来解决 招聘、人员流失、消费者满意度、参与变量，以及 客户和培训师的特征与结果相关。 全国七 公认的顾问已同意支持特定文化 程序开发、实施和数据分析。

DESCRIPTION: (Applicant's Abstract) The goal of this five year research is to provide new knowledge on: 1) the causes of drug use and abuse in inner city African-American and White adolescents, and 2) the most cost-effective and cost-beneficial family-focused prevention interventions. The research aims of this randomized clinical trial involving over 800 at-risk Washington, D.C.-area families of 7 to 11 year olds in components of the 16 week Strengthening Families Program (SFP) are: 1) to test the differential efficacy of the three major components of SFP-parent training (PT), children's skills training (CT), and family skills training (FT) compared to a minimal contact control (MT) on precursors and substance use/abuse employing a 2 x 4 experimental design; 2) to estimate the cost-benefit and cost-effectiveness of the SFP components with 400 African American families and 400 White families; and 3) to empirically test several competing etiological and intervention theories of drug use/abuse underlying the intervention design by analyzing the survey research data from 1,600 12 to 19 year olds and the 800 intervention families using structural equation modeling, mediational analysis, hierarchical linear modeling, latent growth modeling, and transactional modeling (cross-lagged SEM, artificial intelligence, and neural network simulations) for gender, race, and other sub-groups. The rationale for the component design is that a major question exists concerning the efficacy of child-only interventions that group high-risk children together as well as the added benefit of working with the family together compared to parent-training only. Demonstrating the importance of involving parents and working with families would be very valuable information for prevention providers. Additional co-variate outcome analyses will be conducted to answer practical questions conceming the efficacy of the four interventions for different subgroups of clients. A strong process evaluation including a management information system (MIS) conducted by University of Maryland researchers wili document implementation process and provide feedback to improve implementation fidelity. Additional health services sub-aim questions will be addressed through analyses of recruitment, attrition, consumer satisfaction, participation variables, and client and trainer characteristics linked to outcomes. Seven nationally recognized consultants have agreed to support the culturally-specific program development, implementation, and data analyses.