Investigating the impact of insulin resistance on ageing, appearance, and wellbeing using sleep as a model system

使用睡眠作为模型系统来研究胰岛素抵抗对衰老、外观和健康的影响

• 批准号: 1953292
• 金额: --
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1953292
• 关键词: Investigating; impact; insulin; resistance; ageing

Impaired glucose homeostasis, due to reduced insulin sensitivity combined with relative insulin deficiency, is a hallmark of type 2 diabetes. It is also a characteristic feature of ageing and may represent a pivotal mediator of age-related changes in the structural and functional integrity of key organs, including skin and its associated appendages. However understanding on the impact of systemic insulin resistance on cutaneous ageing is limited. The same limitations apply to the biological effects of acute fluctuations in insulin sensitivity, resultant from daily environmental challenge, on skin, its associated appendages and translation to appearance cues. The PhD study aims to examine the impact of insulin resistance on appearance and cutaneous ageing using sleep as a model system. Converging evidence suggests that neuroendocrine changes associated with sleep deprivation may be connected to alterations in insulin sensitivity. This relationship will be examined and disturbances in neuroendocrine regulation explored as a biological mediator of ageing. Apart from the experienced supervisory team at Newcastle University and Unilever UK, the project will benefit from access to the UK BioBank and the Sleepstation (Newcastle's Cognitive Behavioural Therapy programme). The research outcomes have far reaching implications including commercial applications in the Personal Care and Healthcare arenas.This is a multi-disciplinary PhD studentship and includes cellular, molecular biological and physiological techniques such as metabolism measures, histological analysis, image analysis, cell culture, molecular biology, genetic analysis, immunostaining and gene expression studies.

由于胰岛素敏感性降低和相对胰岛素缺乏导致的葡萄糖稳态受损是2型糖尿病的标志。它也是衰老的一个特征，可能是关键器官（包括皮肤及其相关附件）结构和功能完整性与年龄相关变化的关键介质。然而，对全身性胰岛素抵抗对皮肤衰老的影响的了解是有限的。同样的局限性也适用于胰岛素敏感性急性波动的生物学效应，这是由日常环境挑战引起的，对皮肤及其相关附件和外观线索的转化。这项博士研究旨在以睡眠为模型系统，研究胰岛素抵抗对外观和皮肤衰老的影响。越来越多的证据表明，与睡眠剥夺相关的神经内分泌变化可能与胰岛素敏感性的改变有关。这种关系将被检查和神经内分泌调节的干扰探讨作为老化的生物介质。除了纽卡斯尔大学和联合利华英国的经验丰富的监督团队外，该项目还将受益于英国生物银行和睡眠站（纽卡斯尔的认知行为治疗方案）。研究成果具有深远的影响，包括在个人护理和医疗保健领域的商业应用。这是一个多学科的博士生项目，包括细胞，分子生物学和生理技术，如代谢测量，组织学分析，图像分析，细胞培养，分子生物学，遗传分析，免疫染色和基因表达研究。

项目成果

P069 Investigating the impact of insulin resistance on ageing and wellbeing using sleep as a model system

P069 使用睡眠作为模型系统研究胰岛素抵抗对衰老和健康的影响

• DOI: 10.1136/bmjresp-2019-bssconf.69
• 发表时间: 2019
• 作者: Zhu G

Does insomnia worsen cardiometabolic health?

• DOI: 10.47795/vkmr3949
• 发表时间: 2019
• 期刊: Advances in Clinical Neuroscience & Rehabilitation
• 作者: Gewei Zhu;Kirstie Anderson

Mitochondrial protection for health and ageing

线粒体对健康和衰老的保护

• 作者: Zhu G;Ruddy L
• 通讯作者: Ruddy L

Objective sleep assessment in >80,000 UK mid-life adults: Associations with sociodemographic characteristics, physical activity and caffeine.

对超过 80,000 名英国中年成年人进行客观睡眠评估：与社会人口特征、体力活动和咖啡因的关联。

• DOI: 10.1371/journal.pone.0226220
• 发表时间: 2019
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zhu G

Exploration of Sleep as a Specific Risk Factor for Poor Metabolic and Mental Health: A UK Biobank Study of 84,404 Participants.

• DOI: 10.2147/nss.s323160
• 发表时间: 2021
• 期刊: Nature and science of sleep
• 影响因子: 3.4
• 作者: Zhu G;Cassidy S;Hiden H;Woodman S;Trenell M;Gunn DA;Catt M;Birch-Machin M;Anderson KN
• 通讯作者: Anderson KN