In Utero Cocaine Exposure: Child Neurocognitive Outcome

子宫内可卡因暴露：儿童神经认知结果

• 批准号: 6661095
• 负责人: HALLAM HURT
• 金额: $ 2.67万
• 依托单位: ALBERT EINSTEIN HEALTHCARE NETWORK
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6661095
• 关键词: adolescence (12-20); behavioral /social science research tag; child (0-11); child behavior; clinical research; cocaine; cognition; embryo /fetus toxicology; functional magnetic resonance imaging; human subject; longitudinal human study; low socioeconomic status; neuropsychological tests; outcomes research; self destructive behavior; substance abuse related behavior; urban area

DESCRIPTION: (provided by applicant) Children with gestational cocaine exposure do not differ from non-exposed controls on most traditional measures of cognition and behavior. Yet, animal data demonstrating significant cocaine effects on the developing nervous system of the fetus suggest that children with gestational cocaine exposure will differ from controls when cognition is analyzed in terms its distinct neurocognitive systems. The proposed 5-year study will investigate the effect of gestational cocaine exposure on neurocognitive function, examine neural bases of neurocognitive function (fMRI), and explore early substance use in children. The specific aims of this research are: (1) to identify the neurocognitive system(s) most impacted by in utero cocaine exposure; (2) to correlate fMRI findings of both cocaine-exposed and non-exposed children with their neurocognitive assays; (3) to monitor the acquisition of substance use and other risk-taking behaviors; (4) to identify neurocognitive profiles associated with early drug use; and (5) to explore the neural bases of early drug use. Background information regarding growth, development, social and emotional functioning, family dynamics, and acquisition of substance use and risk-taking behaviors will be obtained from standardized medical and psychological assessments. Neuropsychological tasks adapted for use with children will provide behavioral assays of neurocognitive systems. fMRI will provide information about the neural bases of gestational cocaine exposure and early substance use. A cohort of 120 inner city children, followed, since birth, ages 9-11 years, half with gestational cocaine exposure will be administered the battery of medical, psychological, and neurocognitive measures. Fifty of the 120 children will also have fMRI, which will be obtained twice during the study: once early on, as baseline, and once during adolescence. Three teams of investigators will be involved: The PI and team from Albert Einstein Medical Center will maintain longitudinal follow-up of subjects and assess subjects for acquisition of early drug use and other risk behaviors; the Co-PI and team from the Center for Cognitive Neuroscience at the University of Pennsylvania are collaborating to carry out neurocognitive assessments; and the Children's Hospital of Philadelphia team are collaborating to obtain fMRI data. This investigation has both the potential to gain a detailed understanding of the neurocognitive and neural effects of gestational cocaine exposure, as well as to direct investigations and interventions for young children seemingly destined for early drug use and, possibly, addiction.

描述：（申请人提供） 妊娠期接触可卡因的儿童与未接触可卡因的儿童没有区别 控制了大多数传统的认知和行为测量。然而，动物 数据表明可卡因对发育中的神经系统有显著影响 这表明，妊娠期接触可卡因的儿童 与对照组不同， 神经认知系统拟议的5年研究将调查 妊娠期可卡因暴露对神经认知功能的影响， 神经认知功能（fMRI）的基础，并探讨早期物质使用， 孩子本研究的具体目的是：（1）识别 神经认知系统受子宫内可卡因暴露影响最大;（2） 可卡因暴露和未暴露儿童的fMRI结果与 他们的神经认知测定;（3）监测物质使用的获得 和其他冒险行为;（4）识别神经认知特征 与早期药物使用相关;（5）探索早期药物使用的神经基础 吸毒关于增长、发展、社会和经济发展的背景资料 情感功能，家庭动态，物质使用的获得， 冒险行为将从标准化的医疗和 心理评估。神经心理学任务适用于 儿童将提供神经认知系统的行为分析。fMRI将 提供有关妊娠期可卡因暴露的神经基础的信息， 早期使用药物一组120名市中心儿童， 出生，年龄9-11岁，妊娠期可卡因暴露的一半将是 进行了一系列的医学、心理学和神经认知的研究， 措施120名儿童中的50名也将接受功能性磁共振成像， 研究期间两次：一次为早期基线，一次为研究期间 青春期将涉及三个研究者团队：PI和团队 阿尔伯特·爱因斯坦医学中心将保持纵向随访， 受试者并评估受试者早期用药和其他风险 行为;来自认知神经科学中心的Co-PI和团队 宾夕法尼亚大学正在合作进行神经认知 费城儿童医院团队正在合作 获取功能磁共振成像数据这项调查既有可能获得 详细了解妊娠对神经认知和神经的影响 可卡因接触，以及直接调查和干预， 年幼的孩子似乎注定要过早使用毒品，甚至可能上瘾。