Core--Animal

核心--动物

• 批准号: 6563986
• 负责人: CHARLES W TAYLOR
• 金额: $ 29.68万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563986
• 关键词: SCID mouse; animal colony; antineoplastics; biomedical facility; neoplastic growth; pharmacokinetics

Description: (provided by applicant) The purpose of the Animal Core is to provide investigators on this Molecular Targets Program access to mouse models of human tumors and to the technical expertise needed to perform these animal experiments. In the initial years of this grant, the mouse studies will involve pharmacokinetic/pharmacodynamic (PKJPD) evaluations of the drugs and their associated molecular targets as discussed in the specific projects. In future years, as new agents are presented, the Animal Core will evaluate these for antitumor activity and perform PK/PD studies in mouse models. We will primarily use severe combined immune deficient (scid) mouse models, but other mouse systems can also be used. Dr. Charles Taylor and other investigators established a scid mouse colony at the University of Arizona in 1988. Maintaining the colony locally results in tremendous cost savings compared to purchasing scid mice from commercial vendors. The Animal Core (Core C) will provide 3 primary services to the investigators on this grant: 1. Assist with the design of experiments using scid mouse models of human tumor growth and metastasis. 2. Provide technical expertise and consistency in performing scid mouse experiments. 3. Maintain the scid mouse colony and ensure adequate availability of mice for required experiments.

描述：（申请人提供） 动物核心的目的是为研究人员提供有关该分子的 目标计划访问人类肿瘤的鼠标模型和技术 进行这些动物实验所需的专业知识。在最初的几年 这项赠款，小鼠研究将涉及药代动力学/药效学 （PKJPD）对药物及其相关的分子靶标的评估 在特定项目中讨论。在未来的几年中，随着新代理商是 介绍，动物核心将评估它们的抗肿瘤活性和 在小鼠模型中进行PK/PD研究。我们将主要使用严重的组合 免疫缺陷（SCID）鼠标模型，但其他鼠标系统也可以是 用过的。查尔斯·泰勒（Charles Taylor）博士和其他研究人员建立了一只SCID鼠标 1988年在亚利桑那大学的殖民地。在当地维持殖民地 与从购买SCID小鼠相比，从而节省了大量成本 商业供应商。 动物核心（核心C）将为调查人员提供3个主要服务 在这笔赠款中： 1。使用人类的SCID小鼠模型来协助设计实验 肿瘤生长和转移。 2。在执行SCID鼠标方面提供技术专长和一致性 实验。 3。维持SCID小鼠菌落并确保足够的小鼠可用性 对于所需的实验。