CORE--ANIMAL CORE

核心--动物核心

• 批准号: 6103498
• 负责人: PETER K VOGT
• 金额: $ 14.91万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6103498
• 关键词: SCID mouse; animal colony; antineoplastics; athymic mouse; biomedical facility; chemical registry /resource; oncogenes

The Animal Core will be directed by Dr. Pete Vogt and Dr. David Cheresh. The major function of this core will be to examine the anti-tumor activity of compounds developed in mice bearing human tumors. Compounds developed between the Vogt/Cheresh laboratories, will target human tumor growth by targeting the oncogene function within tumor cells, while compounds developed as integrin antagonists will be used to block tumor-induced angiogenesis. The effect of blocking angiogenesis will be further analyzed in terms of anti-tumor activity in two mouse models: 1) the nude mouse model, and 2) the SCID mouse human skin chimeric model.

动物核心将由Pete Vogt博士和David Cheresh博士执导。 该核心的主要功能是检查抗肿瘤活性 在携带人肿瘤的小鼠中发育的化合物。开发了化合物 在Vogt/Cheresh实验室之间，将通过 靶向肿瘤细胞中的癌基因功能，而化合物 作为整联蛋白拮抗剂而开发的将用于阻断肿瘤诱导的 血管生成。将进一步分析阻断血管生成的影响 在两种小鼠模型中的抗肿瘤活性方面：1）裸鼠 模型和2）SCID小鼠人体皮肤嵌合模型。