SIGNALING PATHWAYS & TRANSCRIPTIONAL REGULATION

描述（改编自申请人的摘要）：转录的大 核糖体RNA和核糖体蛋白质mRNA占了 核转录，必须在严格控制下，以防止他们的 在不合适的时间进行能量昂贵的合成。的转录 这些核糖体RNA被协调调节，以确保合成 核糖体成分的化学计量量和蛋白质的最佳水平 合成底物。并阻止它们的能量昂贵的合成， 不合时宜的时候拟议申请的长期目标是 阐明细胞增殖和转录之间的关系， 蛋白质合成机器

DESCRIPTION(adapted from applicant's abstract): Transcription of the large ribosomal RNAs and ribosomal protein mRNAs account for more than 70 percent of nuclear transcription and must be under tight control to prevent their energetically costly synthesis at inappropriate times. The transcription of these ribosomal RNAs is coordinately regulated to ensure the synthesis of stoichiometric amounts of ribosomal components and optimal levels of protein synthetic substrates. And prevent their energetically costly synthesis at inappropriate times. The long term goal of the proposed application is to elucidate the relationship between cell proliferation and transcription of the protein synthetic machinery.