SIGNALING PATHWAYS & TRANSCRIPTIONAL REGULATION

信号通路

• 批准号: 6608833
• 负责人: IAN M WILLIS
• 金额: $ 26.72万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6608833
• 关键词: DNA directed RNA polymerase; Saccharomyces cerevisiae; biological signal transduction; cell growth regulation; cyclins; genetic transcription; ribonuclease III; secretion

DESCRIPTION(adapted from applicant's abstract): Transcription of the large ribosomal RNAs and ribosomal protein mRNAs account for more than 70 percent of nuclear transcription and must be under tight control to prevent their energetically costly synthesis at inappropriate times. The transcription of these ribosomal RNAs is coordinately regulated to ensure the synthesis of stoichiometric amounts of ribosomal components and optimal levels of protein synthetic substrates. And prevent their energetically costly synthesis at inappropriate times. The long term goal of the proposed application is to elucidate the relationship between cell proliferation and transcription of the protein synthetic machinery.

描述(改编自申请人的摘要)：大的 核糖体RNAs和核糖体蛋白mRNAs占70%以上 核转录，必须严格控制，以防止其 在不适当的时间进行耗费精力的合成。的抄写 这些核糖体RNA受到协调调节，以确保合成 核糖体成分的化学计量和蛋白质的最佳水平 合成底物。并防止它们在能量上昂贵的合成 不合适的时间。拟议应用程序的长期目标是 阐明细胞增殖与细胞周期蛋白转录的关系 蛋白质合成机械。