Genetic Architecture of the Mammalian (Canid) Skeleton.

哺乳动物（犬科动物）骨骼的遗传结构。

• 批准号: 6429932
• 负责人: KARL Gordon LARK
• 金额: $ 25.2万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6429932
• 关键词: biotechnology; computer simulation; developmental genetics; dogs; family genetics; gene expression; genetic mapping; genetic polymorphism; genetic regulation; genotype; molecular cloning; phenotype; quantitative trait loci; skeletal system

DESCRIPTION (provided by applicant): The objective of this project is to understand the genetic basis for the morphology and development of the mammalian skeleton. In the process, we should obtain an overview of the genetic architecture of a set of related polygenic traits in a mammal and establish the dog as a useful organism for the study of polygenic phenotypes. Our approach, involving interaction with dog owners, offers an opportunity to create a better public understanding of the research process, the role of genetics in medical research and its impact on every day life. The dog has been chosen as the animal model of choice because of its great range of morphological diversity. Recent progress on its genome has made it possible to relate genetic data on the dog genome to the genome of the human or the mouse and inbred dog populations present ideal populations in which inbreeding has concentrated many of the genes involved in polygenic disease. To determine the genetic architecture underlying the structure of the mammalian skeleton, it will be necessary to identify the multiple genes that regulate skeletal size and shape and to determine the periods during juvenile development when these genes affect growth. The results should be applicable to unraveling genetic aspects of other polygenic human diseases also found in dogs such as cancer, auto-immune disorders (such as Addison's disease), or disorders of the nervous system (such as epilepsy).

描述（由申请人提供）：该项目的目的是 了解形态和发展的遗传基础 哺乳动物骨骼。在此过程中，我们应该获得遗传的概述 哺乳动物中一组相关多基因性状的结构 狗是研究多基因表型的有用生物。我们的方法， 涉及与狗主人的互动，提供了创造更好的机会 公众对研究过程的理解，遗传学在医学中的作用 研究及其对日常生活的影响。 这只狗被选为首选动物模型，因为它的伟大 形态学多样性范围。其基因组的最新进展已取得 可能将狗基因组的遗传数据与人类或人类的基因组联系起来 鼠标和近交狗种群提出了理想的人群 近亲繁殖集中了许多参与多基因疾病的基因。 确定哺乳动物结构的遗传结构 骨骼，有必要识别调节的多个基因 骨骼的大小和形状，并确定少年时期 这些基因影响生长时的发展。结果应适用于 在狗中也发现了其他多基因人类疾病的遗传方面 例如癌症，自身免疫性疾病（例如艾迪生氏病）或疾病 神经系统（例如癫痫）。