SUPERANTIGEN INVOLVEMENT IN PREECLAMPSIA

超抗原参与先兆子痫

• 批准号: 6521211
• 负责人: JULIE A DELOIA
• 金额: $ 15.98万
• 依托单位: MAGEE-WOMEN'S HOSPITAL OF UPMC
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6521211
• 关键词: MHC class II antigen; T lymphocyte; clinical research; disease /disorder etiology; female; human subject; preeclampsia; superantigens; women's health

DESCRIPTION: (Adapted from the Investigator's Abstract): The investigators propose to study a large group of women, including women with pregnancy-induced hypertension that do not progress to preeclampsia as a control group. Longitudinal studies will monitor the occurrence and disappearance of T-cell skewing. They will determine if the hallmarks of a superantigen effect occur in preeclampsia: a) a robust activation of primary T cells; b) MHC class II-dependent response; and c) a TCR Vb-restricted response, in this case, Vb4+ T-cells. Studies will be initiated to define the source of the superantigen by challenging normal T-cells with plasma and syncytiotrophoblast microvillous membrane preparations from preeclamptic patients and monitoring T-cell skewing in vitro.

描述：（改编自研究者摘要）：研究者 我建议研究一大群妇女，包括怀孕引起的妇女， 未进展为先兆子痫高血压患者作为对照组。 纵向研究将监测T细胞的发生和消失， 歪斜他们将确定超抗原效应的标志是否发生在 先兆子痫：a）原代T细胞的强烈活化; B）MHC类 c）TCR Vb限制性应答，在这种情况下，Vb 4 + T细胞将启动研究，通过以下方式确定超抗原的来源 用血浆和合体滋养层微绒毛攻击正常T细胞 来自先兆子痫患者的膜制备物和监测T细胞偏斜 体外