CORE--MOLECULAR NEUROTOXICOLOGY

核心--分子神经毒理学

• 批准号: 6588137
• 负责人: Isaac N Pessah
• 金额: $ 7.35万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-22 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6588137
• 关键词: agriculture worker; apoptosis; biomedical facility; carbamates; chlorohydrocarbon insecticide; environmental toxicology; human subject; insecticide biological effect; insecticides; neurotoxicology; neurotoxins; nicotine; organophosphorus insecticide; protooncogene; pyrethroid; tissue /cell culture

Description (provided by applicant): The major long-term goal of the Molecular Neurotoxicology Research Core is to understand the mechanisms by which complex environmental mixtures may produce direct and indirect neurotoxicity, and their possible influence on increasing the risk of known neurological disorders. To meet this goal, this research core promotes and facilitates interdisciplinary research. The overall objectives of the Molecular Neurotoxicology Research Core are to: (1) Elucidate the molecular and cellular mechanisms that influence the, normal patterns of neuronal signaling, growth, and death. Particular attention will be given to the interaction between the immune and nervous systems. (2) Define how these parameters are altered in response to environmental neurotoxicants, presented either individually or in combination. In this regard, particular attention will be given to chronic, low-level exposures. (3) Initiate studies to understand how genetic factors known to alter immune or nervous system signaling pathways may enhance or diminish susceptibility to the mechanisms elucidated in (1) and (2). The intention of the investigators is to identify key steps involved in cellular signaling that are influenced by environmental pollutants and elucidate how their altered activity may alter specific aspects of neuronal health.

描述（由申请人提供）： 分子神经毒理学研究核心是了解 哪种复杂的环境混合物可能会产生直接和间接的 神经毒性及其对增加已知风险的可能影响 神经系统疾病。为了实现这一目标，该研究核心促进和 促进跨学科研究。总体目标 分子神经毒理学研究核心是：（1）阐明分子 以及影响神经元正常模式的细胞机制 信号，生长和死亡。特别关注 免疫系统和神经系统之间的相互作用。 （2）定义如何 响应于环境神经毒性而改变参数，呈现 单独或组合。在这方面，特别关注 将给予慢性低级暴露。 （3）启动研究 了解如何改变免疫或神经系统已知的遗传因素 信号通路可能会增强或减少对机制的敏感性 在（1）和（2）中阐明。调查人员的目的是确定 受环境影响的细胞信号涉及的关键步骤 污染物并阐明其改变活动可能会改变特定方面 神经元健康。