Assemblies of Self Complementary Structures

自互补结构的组装

• 批准号: 6470797
• 负责人: JULIUS REBEK
• 金额: $ 37.52万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6470797
• 关键词: X ray crystallography; chemical aggregate; chemical binding; chemical models; chemical reaction; chemical structure; chemical synthesis; conformation; covalent bond; high performance liquid chromatography; hydrogen bond; intermolecular interaction; molecular assembly /self assembly; molecular shape; molecular size; nuclear magnetic resonance spectroscopy; stereoisomer; structural biology; thermodynamics

DESCRIPTION: (provided by applicant) This proposal deals with chemically synthesized systems known as encapsulation complexes. They involve weakly bound assemblies in which a host structure completely surrounds one or more molecular guests. These systems are formed reversibly and exist on time scales of milliseconds to days, long enough for many types of interactions, and even reactions to take place within them. The encapsulated molecules are temporarily isolated and their behavior is effected accordingly: their motions and reactions are limited to the capsule, and they are protected from reagents inthe exterior solution or in other capsules. These features are relevant to molecular recognition, computational chemistry, low-barrier hydrogen bonds, autocatalysis and the rules governing molecular assembly. They have counterparts in biology: molecules-within-molecules resemble substrates surrounded by enzymes and agonists surrounded by receptors. They are all dynamic systems, largely shielded from solvent, in which motions are limited and interactions like hydrogen bonds may be magnified. The encapsulation complexes can also show nonlinear properties such as autocatalysis that are characteristic of living systems. The encapsulation of peptides and nucleic acid derivatives takes a step toward the use of these systems for drug delivery. We intend to study how the capsules recognize their guests, how the guest molecules get into and out of the capsules, the nature of the space inside the capsules, their transport properties. We also propose to synthesize new and larger capsules, especially those made up of many identical molecular subunits.

描述：（由申请人提供）本提案涉及化学 合成系统称为封装复合物。它们涉及弱束缚 主体结构完全包围一个或多个分子的组装体， 客人这些系统是可逆形成的，存在于时间尺度上， 毫秒到几天，足够长的时间进行许多类型的交互，甚至 反应发生在他们身上。被包裹的分子暂时 因此，它们的运动和反应被限制在胶囊内，并且它们受到保护，免受外部溶液或其他胶囊中的试剂的影响。 这些特征与分子识别，计算化学， 低垒氢键、自催化和分子调控规则 组装件.它们在生物学中也有对应物：分子中的分子 类似于被酶包围的底物和被受体包围的激动剂。 它们都是动态系统，基本上不受溶剂的影响， 是有限的，像氢键的相互作用可能会被放大。的 包封复合物还可以显示非线性性质， 自动催化是生命系统的特征。的封装 肽和核酸衍生物向使用这些肽和核酸衍生物迈出了一步。 药物输送系统。我们打算研究这些胶囊是如何识别它们的 客人，客人分子如何进出胶囊， 胶囊内部的空间，它们的传输特性。我们亦建议 合成新的和更大的胶囊，特别是那些由许多相同的 分子亚基