ASSEMBLY OF SELF-COMPLEMENTARY STRUCTURES

自互补结构的组装

• 批准号: 2187821
• 负责人: JULIUS REBEK
• 金额: $ 15.21万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2187821
• 关键词: chemical binding; chemical models; chemical structure; chemical synthesis; intermolecular interaction; molecular shape

Self-assembly is one of the common features of biological macromolecule, and frequently the super structures are made of self-complementary modules. Here complementarity refers to sizes, shapes and chemical surfaces involved in molecular recognition phenomena. In this proposal we explore the synthesis of self-complementary systems from small molecule modules whose geometry and orientation of recognition surface permits assembly into closed-shell superstructures. In this our premise is that the assembly process is most likely to yield to model systems; molecules that can be synthesized interpreted and manipulated with a high degree of structural certainty. We intend to prepare several simple modules and determine how their assembly into host species is dependent on their recognition surfaces, shapes and the presence of their respective guests. The long-term goals are to transport across membranes with these molecules, and their use as reaction chambers for the catalysis of biorelevant processes. The shorter term goals involve the application of results in two dimensional hydrogen bond arrays to the synthesis of three dimensional structures capable of reversible assembly and inclusion phenomena.

自组装是生物大分子的共同特征之一， 通常，超级结构是由自互补的 模块。 这里的互补性指的是大小、形状和化学性质 表面参与分子识别现象。 本提案中 我们探索了自互补系统的合成， 识别表面的几何形状和方向的分子模块 允许组装成封闭的壳体上部结构。 在这个前提下， 装配过程最有可能屈服于模型系统; 分子，可以合成，解释和操纵， 结构的确定性。 我们打算准备几个简单的 模块，并确定它们组装成宿主物种是如何依赖于 在它们的识别表面，形状和它们的存在， 各自的客人。 长期目标是跨膜运输 用这些分子，以及它们作为反应室的用途， 生物相关过程的催化作用。 短期目标包括： 应用二维氢键阵列的结果， 可逆组装三维结构的合成 和包容现象。