Synthetic TIR Domain Mimetics as a Novel Strategy for Intervention in Sepsis

合成 TIR 结构域模拟物作为干预脓毒症的新策略

• 批准号: 8128306
• 负责人: JULIUS REBEK
• 金额: $ 39.02万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128306
• 关键词: Acute Lung Injury; Adaptor Signaling Protein; Animal Model; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Antibiotics; Attenuated; Binding; Cell Line; Cell model; Cells; Cessation of life; Clinical; Coagulation Process; Collection; Conserved Sequence; Cytokine Network Pathway; Down-Regulation; Drug Kinetics; Equilibrium; Family; Fever; Functional disorder; Goals; Hand; Host Defense; Immune; Immune response; Immune system; Infection; Inflammation; Inflammatory; Inflammatory Response; Interleukin Receptor; Interleukin-1; Interleukin-1 Receptors; Interleukins; Interruption; Intervention; Lead; Libraries; Ligands; Mediating; Modeling; Modification; Molecular Conformation; Molecular Weight; Myelogenous; Nodal; Nucleotides; Organ failure; Outcome; Pathogenesis; Patients; Pattern Recognition; Play; Property; Reaction; Receptor Signaling; Recruitment Activity; Research; Role; Sepsis; Sepsis Syndrome; Signal Pathway; Signal Transduction; Signaling Molecule; Structure; Structure-Activity Relationship; Surface; Syndrome; System; Testing; Tissues; Toll-like receptors; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; Vascular System; analog; attenuation; base; complement pathway; coping; cytokine; in vivo; member; microbial; mimetics; novel strategies; pathogen; potency testing; prevent; public health relevance; receptor; response; treatment strategy