ASSEMBLIES OF SELF COMPLEMENTARY STRUCTURES

自互补结构的组装

• 批准号: 6018976
• 负责人: JULIUS REBEK
• 金额: $ 25.17万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6018976
• 关键词: Diels Alder reaction; X ray crystallography; chemical binding; chemical models; chemical structure; chemical synthesis; conformation; covalent bond; dimer; high performance liquid chromatography; hydrogen bond; intermolecular interaction; molecular shape; molecular size; nuclear magnetic resonance spectroscopy; stereoisomer; thermodynamics

This application seeks continued support for studies of synthetic molecular assemblies. The assemblies are reversibly formed dimers of self-complementary molecules and are held together through weak intermolecular forces. The assemblies become closed-shell structures that act to encapsulate smaller molecules. The syntheses of these capsules of various sizes, shapes and solubilities are proposed and the behavior of their assemblies are to be determined. The specific issues to be addressed involve the effects of functional groups on guest binding; dynamic processes such as rates into and out of the capsules and molecular motions within the capsule by the guest; the use of the capsules as reaction chambers to catalyze rearrangements; the capacities of the capsules as asymmetric microenvironments, and their use as sensors or signaling devices. Many of the phenomena observed with these synthetic systems mimic those of naturally occurring assemblies such as allosteric enzymes and viral coat proteins. It is hoped that the rules governing the assembly process and the phenomena such as selection, transport and catalysis which owe their existence to the assembly, can be deciphered with the synthetic systems.

本申请寻求对合成的聚乙二醇的研究的持续支持。 分子组装组装体是可逆形成的二聚体 自我互补的分子，并保持在一起， 弱分子间力组件成为封闭壳层 这些结构可以包裹更小的分子。的合成 在这些不同尺寸、形状和溶解度的胶囊中， 建议和其组件的行为将被确定。 要解决的具体问题涉及职能的影响， 客户绑定的组;动态过程，如进入和 从胶囊和胶囊内的分子运动， 客人;使用胶囊作为反应室催化 重排;胶囊的能力作为不对称的 微环境，以及它们作为传感器或信号装置的用途。 在这些合成系统中观察到的许多现象 模仿那些天然存在的组装体， 酶和病毒外壳蛋白。我们希望， 装配过程和选择等现象， 运输和催化，它们的存在归功于装配， 都可以用合成系统破译