HYPERPOLARIZED HELIUM-3 MRI OF THE LUNG IN ASTHMATICS

哮喘患者肺部超极化氦 3 MRI

• 批准号: 6537948
• 负责人: EDUARD E DE LANGE
• 金额: $ 43.74万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537948
• 关键词: albuterol; allergens; asthma; autoradiography; bioimaging /biomedical imaging; computed axial tomography; exercise; helium; human subject; human therapy evaluation; inhalation drug administration; lung imaging /visualization /scanning; magnetic resonance imaging; methacholine; nuclear medicine; patient oriented research; prognosis; pulmonary respiration; respiratory disease /disorder therapy; respiratory disorder chemotherapy; sign /symptom; triamcinolone

DESCRIPTION (Verbatim from the Applicant's Abstract): Asthma is an important public health concern affecting more than l4 million people in the United States including over 4.8 million children. Epidemiological studies show a trend toward increasing prevalence and morbidity, but the reasons for these increases remain unclear. Asthma is a chronic disease defined by reversible obstruction of the small airways, inflammation, and increased airway responsiveness to a variety of stimuli: a process that disrupts adequate ventilation of the alveoli causing dyspnea and hypoxia. Existing methods of small airways disease are either indirect or imprecise. Hyperpolarized helium-3 (H3He) gas MR lung imaging is a new technology which allows direct visualization of the lung airspaces, the ventilation and small airway disease, enabling assessment of disease activity at a level that was previously impossible to evaluate. Thus, H3He MR imaging has the potential to provide insight into the pathophysiology of asthma and to contribute to improved clinical management. Preliminary studies with H3He MR have demonstrated ventilation defects in asthmatics, even when they were asymptomatic and had normal lung function tests, and the findings suggest that this new technology is capable of detecting subclinical disease. The goal of the proposed research is to gain a better insight into the H3He MR imaging characteristics in asthmatics (Specific Aim # 1) and to determine how these findings correlate with disease activity and severity (Specific Aim #2). In order to obtain information on the imaging characteristics, we will evaluate the H3He MR imaging findings in populations of symptomatic and asymptomatic asthmatics, using healthy, non-asthmatics as controls. In addition, we will determine in small subgroups of patients how these findings compare to those obtained with two existing lung imaging modalities, nuclear medicine ventilation scanning and computed tomography (CT). To determine the ability of H3He lung MR in assessing disease activity, we will evaluate the imaging changes that occur during tests that provoke (worsen) and treat (improve) asthma. Provocation tests include inhalation of methacholine, exercise, administration of endobronchial allergen and viral inoculation, and treatments include inhaled of p2agonist (albuterol) and steroids (asthmacort). The results of the studies proposed in this research will serve as a foundation for developing future clinical and basic research applications.

描述（来自申请人摘要的逐字）：哮喘是一种重要的 影响美国1400多万人的公共卫生问题 包括480多万儿童。流行病学研究表明， 流行率和发病率上升的趋势，但这些原因 增长仍不清楚。哮喘是一种慢性疾病， 小气道阻塞、炎症和气道增加 对各种刺激的反应：一个过程，破坏了足够的 肺泡通气导致呼吸困难和缺氧。的现有方法 小气道疾病是间接的或不精确的。超极化氦-3 （H3 He）气体MR肺成像是一种新技术， 肺空间的可视化，通气和小气道疾病， 使疾病活动评估达到以前的水平， 无法评估。因此，H3 He MR成像具有提供 了解哮喘的病理生理学，并有助于改善 临床管理H3 He MR的初步研究表明， 哮喘患者的通气缺陷，即使他们没有症状， 正常的肺功能测试，研究结果表明，这项新技术， 能够检测亚临床疾病。 该研究的目的是更好地了解H3 He MR 哮喘患者的影像学特征（具体目标#1），并确定如何 这些发现与疾病活动性和严重性相关（具体目标#2）。 为了获得有关成像特征的信息，我们将评估 有症状和无症状人群的H_3He MRI表现 哮喘患者，以健康的非哮喘患者作为对照。此外，我们会 在小的患者亚组中确定这些结果与那些 通过两种现有的肺部成像方式获得，核医学 通气扫描和计算机断层扫描（CT）。指为确定 H3 He肺MR评估疾病活动性，我们将评估成像 在测试期间发生的引起（恶化）和治疗（改善）的变化 哮喘激发试验包括吸入乙酰甲胆碱，运动， 给予支气管内变应原和病毒接种，以及治疗 包括吸入β 2激动剂（沙丁胺醇）和类固醇（哮喘可）。结果 本研究中提出的研究将作为基础， 开发未来的临床和基础研究应用。