HYPERPOLARIZED HELIUM-3 MRI OF THE LUNG IN ASTHMATICS

哮喘患者肺部超极化氦 3 MRI

• 批准号: 6580182
• 负责人: EDUARD E DE LANGE
• 金额: $ 0.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580182
• 关键词: albuterol; allergens; asthma; autoradiography; bioimaging /biomedical imaging; computed axial tomography; exercise; helium; human subject; human therapy evaluation; inhalation drug administration; lung imaging /visualization /scanning; magnetic resonance imaging; methacholine; nuclear medicine; patient oriented research; prognosis; pulmonary respiration; respiratory disease /disorder therapy; respiratory disorder chemotherapy; sign /symptom; triamcinolone

DESCRIPTION (Verbatim from the Applicant's Abstract): Asthma is an important public health concern affecting more than l4 million people in the United States including over 4.8 million children. Epidemiological studies show a trend toward increasing prevalence and morbidity, but the reasons for these increases remain unclear. Asthma is a chronic disease defined by reversible obstruction of the small airways, inflammation, and increased airway responsiveness to a variety of stimuli: a process that disrupts adequate ventilation of the alveoli causing dyspnea and hypoxia. Existing methods of small airways disease are either indirect or imprecise. Hyperpolarized helium-3 (H3He) gas MR lung imaging is a new technology which allows direct visualization of the lung airspaces, the ventilation and small airway disease, enabling assessment of disease activity at a level that was previously impossible to evaluate. Thus, H3He MR imaging has the potential to provide insight into the pathophysiology of asthma and to contribute to improved clinical management. Preliminary studies with H3He MR have demonstrated ventilation defects in asthmatics, even when they were asymptomatic and had normal lung function tests, and the findings suggest that this new technology is capable of detecting subclinical disease. The goal of the proposed research is to gain a better insight into the H3He MR imaging characteristics in asthmatics (Specific Aim # 1) and to determine how these findings correlate with disease activity and severity (Specific Aim #2). In order to obtain information on the imaging characteristics, we will evaluate the H3He MR imaging findings in populations of symptomatic and asymptomatic asthmatics, using healthy, non-asthmatics as controls. In addition, we will determine in small subgroups of patients how these findings compare to those obtained with two existing lung imaging modalities, nuclear medicine ventilation scanning and computed tomography (CT). To determine the ability of H3He lung MR in assessing disease activity, we will evaluate the imaging changes that occur during tests that provoke (worsen) and treat (improve) asthma. Provocation tests include inhalation of methacholine, exercise, administration of endobronchial allergen and viral inoculation, and treatments include inhaled of p2agonist (albuterol) and steroids (asthmacort). The results of the studies proposed in this research will serve as a foundation for developing future clinical and basic research applications.

描述(逐字摘自申请者摘要)：哮喘是一个重要的公共卫生问题，影响着美国超过1400万人 各州，包括超过480万名儿童。流行病学研究表明， 有增加患病率和发病率的趋势，但造成这些的原因 增长情况仍不明朗。哮喘是一种慢性疾病，其定义是可逆的 小气道阻塞、炎症和对各种刺激的气道反应性增强：这一过程扰乱了足够的 肺泡通风导致呼吸困难和缺氧。现有的方法 小气道疾病要么是间接的，要么是不准确的。超极化氦-3 (H3He)气体磁共振肺成像是一种新技术，它可以直接 肺空间、通风和小气道疾病的可视化， 能够在以前的水平上评估疾病活动 无法评估。因此，H3He磁共振成像有可能提供 深入了解哮喘的病理生理学，并为改进 临床管理。对H3He MR的初步研究表明 哮喘患者的通风缺陷，即使他们没有症状和 正常的肺功能测试，结果表明这项新技术 能够检测出亚临床疾病。 拟议研究的目的是为了更好地了解H3He MR 哮喘患者的影像特征(特定目标1)以及如何确定 这些发现与疾病的活动性和严重性相关(具体目标2)。 为了获得有关成像特征的信息，我们将评估 有症状和无症状人群的H3He磁共振影像表现 哮喘患者，以健康的非哮喘患者为对照。此外，我们还将 在一小群患者中确定这些发现与那些 通过两种现有的肺部成像方式获得，核医学 通风扫描和计算机断层扫描(CT)。确定…的能力 H3He肺部磁共振在评估疾病活动性时，我们将评估其成像 在引发(恶化)和治疗(改善)测试期间发生的变化 哮喘。激发测试包括吸入乙酰甲胆碱，运动， 支气管内变应原和病毒接种的管理及治疗 包括吸入p2激动剂(沙丁胺醇)和类固醇(喘息痛)。结果是 这项研究中提出的研究的部分将作为 开发未来的临床和基础研究应用。