ROLE OF BIOMECHANICS/NEURAL PLASTICITY IN RADICULAR PAIN

生物力学/神经可塑性在根性疼痛中的作用

• 批准号: 6531021
• 负责人: Beth A Winkelstein
• 金额: $ 0.95万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6531021
• 关键词: backache; biomechanics; cytokine; enzyme linked immunosorbent assay; laboratory rat; lumbar plexus; neural plasticity; spinal ganglion

The mechanism of low back pain is believed to involve a mechanical component. However, there is an incomplete understanding of the local mechanical response of neural tissue and no defined threshold of mechanical loading of individual tissue structures for pain onset and maintenance. While animal models are presently used to examine radiculopathy, the extent of damage to the lumbar nerve roots, dorsal root ganglia ~ nerves in these models remains solely qualitative in nature. It is the broad aim of this work to examine mechanical factors influencing local tissue injury in a rat model of lumbar radiculopathy by (1) characterizing the time course of local tissue mechanics and the associated pain response for loading to the lumbar nerve root, dorsal root ganglion, and spinal nerve, (2) quantifying the differences in mechanical and physiologic responses for ligation of the lumbar nerve root using loose, tight, and chromic gut sutures, (3) determining compression load thresholds for onset and maintenance of a pain response. Mechanical tissue deformation data will be acquired by imaging at the time of injury and at time points following surgery. age analysis will be used to determine the local strain tensor for particular tissue components. Tissue bins will be correlated with mechanical allodynia and neuroimmune mediators of persistent pain.

下背痛的机制被认为涉及机械组件。然而，对神经组织的局部机械反应的理解不完全，并且没有定义用于疼痛发作和维持的个体组织结构的机械负荷的阈值。虽然目前使用动物模型来检查神经根病，但是在这些模型中对腰神经根、背根神经节神经的损伤程度本质上仍然仅仅是定性的。本工作的主要目的是通过以下方式检查影响腰椎神经根病大鼠模型中局部组织损伤的机械因素：（1）表征局部组织力学的时程和对腰椎神经根、背根神经节和脊神经的负荷的相关疼痛反应，（2）量化使用松质、松质和非松质材料结扎腰椎神经根的机械和生理反应的差异，紧的和铬肠线，（3）确定疼痛反应开始和维持的压缩负荷阈值。将在损伤时和手术后的时间点通过成像采集机械组织变形数据。年龄分析将用于确定特定组织成分的局部应变张量。组织箱将与机械性异常性疼痛和持续性疼痛的神经免疫介质相关。