Local Tissue Biomechanics in Low Back & Radicular Pain
腰部局部组织生物力学
基本信息
- 批准号:6785221
- 负责人:
- 金额:$ 12.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-09-19 至 2006-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by the applicant): This application aims to test
hypotheses regarding low back pain while also increasing the candidate?s skills
in pain and neurophysiologic research. As an independent researcher, she
proposes a plan that will help in the transition to an independent researcher,
combining both focused research and career development activities. Her
long-term career goal is the development of an independent research program
studying painful neck injury biomechanics. Immediate goals for achieving this
are provided in a career development plan for this award that include both
courses related to neurobiology and research directly related to low back pain.
Under the mentorship of Dr. DeLeo, she proposes to incorporate these activities
in her training and research. Dartmouth is said to be an ideal environment for
such activities due to Dr. DeLeo?s leadership in the pain field and the
institution as a whole having much collaboration between Anesthesiology, the
Spine Center, and the Thayer School of Engineering. The proposed research
incorporates aspects of biomechanics and the neuroimnmunology of pain to test
the central hypothesis that lumbar radioculopathy depends on local nerve root
deformation and central neuroplasticity that is directly influenced by the
initial tissue deformation magnitude. While mechanisms of low back and
radicular pain are believed to involve a mechanical component, there is an
incomplete understanding of the local mechanical response of neural tissue in
these diseases. The proposed work combines studying neuroinflammatory
mechanisms leading to spinal sensitization with bioengineering analysis of
tissue injury. An existing rat model of lumbar radioculopathy is utilized to:
(1) quantify and correlate differences in mechanical and spinal neuroimmune
activation responses for non-inflammatory and inflammatory compressive insults,
(2) quantitatively assess reproducibility in applying a nerve root injury, (3)
determine local tissue mechanics and subsequent neuroinflammation associated
with acute and chronic radicular pain states, and (4) use these data to develop
both strain-based and load-based criteria for painful nerve root injury. To
accomplish this, in vivo tissue strains will be correlated with mechanical
allodynia and neuroimmune mediators of persistent pain.
描述(申请人提供):本申请旨在测试
关于腰痛的假设,同时也增加了候选人?S的技能?
在疼痛和神经生理学研究方面。作为一名独立研究员,她
提出了一项有助于向独立研究人员过渡的计划,
将重点研究和职业发展活动结合起来。她
长期的职业目标是发展一个独立的研究项目
研究痛性颈部损伤的生物力学。实现这一目标的近期目标
在该奖项的职业发展计划中提供,其中包括
与神经生物学相关的课程和与下腰痛直接相关的研究。
在德利奥博士的指导下,她提议将这些活动纳入
在她的训练和研究中。达特茅斯据说是一个理想的环境,
这样的活动归功于德利奥?S博士在疼痛领域的领导和
机构作为一个整体在麻醉学、
脊椎中心和塞耶工程学院。拟议的研究
将生物力学和疼痛的神经免疫学结合起来进行测试
腰椎放射性眼病依赖于局部神经根的中心假设
变形和中枢神经可塑性直接受
初始组织变形量。而腰背部和腰部的机制
根性疼痛被认为涉及机械部件,有一种
对神经组织局部力学反应的不完全认识
这些疾病。拟议的工作结合了对神经炎性疾病的研究
脊椎敏化机制的生物工程分析
组织损伤。现有的大鼠腰椎放射眼病模型用于:
(1)量化和关联机械神经免疫和脊髓神经免疫的差异
非炎症性和炎症性压迫性侮辱的激活反应,
(2)定量评估应用神经根损伤的可重复性;(3)
确定局部组织力学和随后相关的神经炎症
急性和慢性神经根性疼痛状态,以及(4)使用这些数据开发
疼痛神经根损伤的标准包括基于应变和基于负荷的。至
做到这一点,体内的组织应变将与机械相关
痛觉过敏和持续性疼痛的神经免疫介质。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The role of graded nerve root compression on axonal damage, neuropeptide changes, and pain-related behaviors.
- DOI:10.4271/2008-22-0002
- 发表时间:2008-11
- 期刊:
- 影响因子:0
- 作者:R. D. Hubbard;K. Quinn;J. J. Martínez-J.;B. Winkelstein
- 通讯作者:R. D. Hubbard;K. Quinn;J. J. Martínez-J.;B. Winkelstein
Controlled release of GDNF reduces nerve root-mediated behavioral hypersensitivity.
- DOI:10.1002/jor.20710
- 发表时间:2009-01
- 期刊:
- 影响因子:2.8
- 作者:Hubbard, Raymond D.;Martinez, Joan J.;Burdick, Jason A.;Winkelstein, Beth A.
- 通讯作者:Winkelstein, Beth A.
Cytokine mRNA expression in painful radiculopathy.
- DOI:10.1016/j.jpain.2008.07.008
- 发表时间:2009-01
- 期刊:
- 影响因子:0
- 作者:Rothman SM;Huang Z;Lee KE;Weisshaar CL;Winkelstein BA
- 通讯作者:Winkelstein BA
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{{ truncateString('Beth A Winkelstein', 18)}}的其他基金
MEASURING LIGAMENT FIBER ORIENTATION USING SHG
使用 SHG 测量韧带纤维方向
- 批准号:
8362577 - 财政年份:2011
- 资助金额:
$ 12.52万 - 项目类别:
A Novel Model of TMJ Osteoarthritis to Define Glial Reactivity in Chronic Pain
一种新的颞下颌关节骨关节炎模型来定义慢性疼痛中的神经胶质反应
- 批准号:
7244043 - 财政年份:2006
- 资助金额:
$ 12.52万 - 项目类别:
A Novel Model of TMJ Osteoarthritis to Define Glial Reactivity in Chronic Pain
一种新的颞下颌关节骨关节炎模型来定义慢性疼痛中的神经胶质反应
- 批准号:
7152095 - 财政年份:2006
- 资助金额:
$ 12.52万 - 项目类别:
Biomechanical Mechanisms of /facts-Mediated Whiplash In*
/事实介导的颈椎扭伤的生物力学机制*
- 批准号:
7277668 - 财政年份:2005
- 资助金额:
$ 12.52万 - 项目类别:
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