TOTAL SYNTHESIS OF SCABRONINE A

SCABRONINE A 的全合成

• 批准号: 6477292
• 负责人: GREGORY B DUDLEY
• 金额: $ 2.03万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2002-06-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6477292
• 关键词: chemical synthesis; diterpenes; nerve growth factors; stereochemistry; stimulant /agonist

This proposal outlines a strategy for the enantioselective synthesis of (-)- scarbronine A, a complex diterpenoid natural product. The scabronine compounds are potent stimulators of nerve growth factor-synthesis, making them potential therapeutic agents for a variety of nervous system disorders. The proposed strategy utilizes a novel coupling annulation to assemble the seven-membered ring.

该建议概述了一种对映选择性合成（-）-赤藓红A，一个复杂的二萜类天然产物的策略。该化合物是神经生长因子合成的有效刺激剂，使其成为各种神经系统疾病的潜在治疗剂。所提出的策略利用一种新的耦合成环组装的七元环。

项目成果

A stereoselective route to guanacastepene A through a surprising epoxidation

• DOI: 10.1002/1521-3773(20020617)41:12<2188::aid-anie2188>3.0.co;2-j
• 发表时间: 2002-01-01
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Lin, SN;Dudley, GB;Danishefsky, SJ
• 通讯作者: Danishefsky, SJ

Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization.

胍那卡斯特烯 A 的官能化三环骨架的合成：串联环氧化物开环 β-消除/克诺文格尔环化。

• 发表时间: 2002
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Tan,DerekS;Dudley,GregoryB;Danishefsky,SamuelJ
• 通讯作者: Danishefsky,SamuelJ