Dental Amalgam

牙科汞合金

• 批准号: 6501688
• 负责人: ALBERT KINGMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6501688
• 关键词: biomaterial evaluation; blood chemistry; clinical research; dental amalgam; dental disorder diagnosis; human subject; male; mercury; mercury poisoning; oral health; toxicant interaction; toxicology; urinalysis; veterans

The clinical areas of primary focus of the NIDCR study include the neurological, renal, endocrine, immunological, and numerous psychological conditions. The oral health examination included an assessment of caries, soft-tissue lesions, and a complete tooth and surface based inventory of dental restorative materials, including amalgams. This study, a collaboration with the U.S. Air Force, involves a multi-disciplinary team of mercury toxicologists, neurologists, psychologists, immunologists, statisticians, laboratory experts, other medical specialists and clinical dentists. The mean age of the 1,166 study participants was 52.8 years. Overall, 5.2 percent of the participants were edentulous. Dentate individuals averaged 19.9 amalgam surfaces per person, with amalgam contributing slightly more than one-half of all restored surfaces in dentate individuals. We estimate that this cohort has a higher exposure to dental amalgams than their age-matched U.S. male population. The total mercury level in urine was 3.1 mg per liter and 2.6 mg for whole blood. A clear dose-response was observed between the levels of mercury (total and inorganic) in urine and the amount of exposure to amalgam. The frequency of abnormal neurological conditions was very low, with most response measures affecting between 1 and 5 percent of these participants. There was no evidence of a clear dose-response relationship between amalgam exposure and the level of neurological abnormalities. A couple of specific response measures associated with amalgam exposure, but these were inconsistently manifested among various subgroups, being both positively or negatively associated with amalgam levels. As a consequence of external expert reviews further analyses incorporating important exclusionary criteria (previously unavailable, but recently incorporated into the databases) are in the final stages. The major findings of this study will be important to validate. A second examination of the full study cohort of 2,200 participants is underway in an attempt to better delineate the significance of the associations detected on the first cycle. These examinations were completed in the spring of 1998. The oral health data were received from the contractor and are being edited in consultation with the Contractor. The neurological data have been received from the Air Force and the creation of the databasess has begun. Computer programs are currently being written to analyze these data. The effects of amalgam exposure on the neurological measures is currently being investigated.

NIDCR研究主要关注的临床领域包括神经、肾脏、内分泌、免疫和许多心理疾病。口腔健康检查包括评估龋齿、软组织病变以及完整的牙齿和基于表面的牙科修复材料清单，包括汞合金。这项与美国空军合作的研究涉及汞毒理学家，神经学家，心理学家，免疫学家，统计学家，实验室专家，其他医学专家和临床牙医的多学科团队。1,166名研究参与者的平均年龄为52.8岁。总的来说，5.2%的参与者是缺牙的。有牙个体平均每人19.9汞合金表面，汞合金贡献略多于有牙个体所有修复表面的一半。我们估计，这一队列的牙科汞合金暴露量高于其年龄匹配的美国男性人群。尿中的总汞含量为每升3.1毫克，全血中为2.6毫克。尿液中汞（总汞和无机汞）含量与汞合金接触量之间存在明显的剂量反应关系。神经系统异常的频率非常低，大多数反应措施影响了这些参与者的1%到5%。没有证据表明汞合金暴露与神经系统异常水平之间存在明确的剂量反应关系。有几项具体的应对措施与汞合金接触有关，但这些措施在不同的分组中表现得并不一致，与汞合金含量有正相关或负相关。由于外部专家的审查，纳入重要排除标准（以前没有，但最近纳入数据库）的进一步分析已进入最后阶段。这项研究的主要发现将是重要的验证。对2,200名参与者的整个研究队列的第二次检查正在进行中，试图更好地描述第一个周期检测到的关联的重要性。这些检查于1998年春季完成。口腔健康数据是从承包者收到的，目前正在与承包者协商编辑。神经学数据已经从空军收到，数据库的创建已经开始。目前正在编写计算机程序来分析这些数据。目前正在研究汞合金暴露对神经测量的影响。