The NIDCR/USAF Dental Amalgam Study

NIDCR/USAF 牙科汞合金研究

• 批准号: 6104628
• 负责人: ALBERT KINGMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6104628
• 关键词: biomaterial evaluation; blood chemistry; clinical research; dental amalgam; dental disorder diagnosis; human subject; male; mercury; mercury poisoning; neurotoxicology; oral health; toxicant interaction; toxicology; urinalysis; veterans

The clinical areas of primary focus of the NIDCR study include the neurological, renal, endocrine, immunological, and numerous psychological conditions. The oral health examination included an assessment of caries, soft-tissue lesions, and a complete tooth and surface based inventory of dental restorative materials, including amalgams. This study, a collaboration with the U.S. Air Force, involves a multi-disciplinary team of mercury toxicologists, neurologists, psychologists, immunologists, statisticians, laboratory experts, other medical specialists and clinical dentists. The mean age of the 1,166 study participants was 52.8 years. Overall, 5.2 percent of the participants were edentulous. Dentate individuals averaged 19.9 amalgam surfaces per person, with amalgam contributing slightly more than one-half of all restored surfaces in dentate individuals. We estimate that this cohort has a higher exposure to dental amalgams than their age-matched U.S. male population. The total mercury level in urine was 3.1 mg per liter and 2.6 mg for whole blood. A clear dose-response was observed between the levels of mercury (total and inorganic) in urine and the amount of exposure to amalgam. The frequency of abnormal neurological conditions was very low, with most response measures affecting between 1 and 5 percent of these participants. There was no evidence of a clear dose-response relationship between amalgam exposure and the level of neurological abnormalities. A couple of specific response measures associated with amalgam exposure, but these were inconsistently manifested among various subgroups, being both positively or negatively associated with amalgam levels. As a consequence of external expert reviews further analyses incorporating important exclusionary criteria (previously unavailable, but recently incorporated into the databases) are in the final stages. The major findings of this study will be important to validate. A second examination of the full study cohort of 2,200 participants is underway in an attempt to better delineate the significance of the associations detected on the first cycle. These examinations were completed in the spring of 1998.

NIDCR主要关注的临床领域 研究包括神经，肾脏，内分泌，免疫， 还有很多心理问题口腔健康 检查包括评估龋齿，软组织损伤， 以及完整的牙齿和基于表面的牙科 修复材料，包括汞合金。本研究 与美国空军的合作，涉及多学科 汞毒理学家，神经学家，心理学家， 免疫学家、统计学家、实验室专家、其他医学专家 专家和临床牙医。1,166名研究对象的平均年龄 参与者年龄为52.8岁。总体而言，5.2%的参与者 都是缺牙的有齿个体平均19.9汞合金 汞合金的贡献略高于 牙齿个体中所有修复表面的一半。我们估计 这一群体接触牙科汞合金的比例高于 年龄匹配的美国男性人口。尿中总汞含量 每升3.1毫克，全血2.6毫克。一个明确 在汞水平（总汞）之间观察到剂量-反应 和无机物）以及汞合金暴露量。 神经系统异常的发生率很低， 大多数应对措施影响到1%至5%的 这些参与者。没有明显的剂量反应证据 汞合金接触与汞含量之间的关系 神经系统异常一些具体的应对措施 与汞合金暴露有关，但这些并不一致 在不同的亚组中表现出来，无论是积极的还是 与汞合金含量呈负相关。的结果 外部专家审查进一步分析， 排除标准（以前不可用，但最近 已纳入数据库）已进入最后阶段。主要 这项研究的结果将是重要的验证。第二 对2,200名参与者的整个研究队列的检查是 正在进行中，试图更好地描绘的意义， 在第一个周期检测到的关联。这些检查 于1998年春季完成。