Additive Manufacture for Medical Engineering

医学工程增材制造

• 批准号: 2059409
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2059409
• 关键词: Additive; Manufacture; Medical; Engineering

In orthopaedic surgery, we repair, reconstruct or replace parts of human joints. This requires fixing different types of implants to the bone. Conventional manufacture of orthopaedic implants has been from solid Titanium CoCrMo allloys or ceramics, which are many times stiffer than the bone. But bone is a material that responds to strain, and thus these materials have limitations. Exciting new work in our research group has proven that we can make additively manufactured (AM) lattice parts that are the same stiffness as bone and bone formation has been controlled in an animal model through the strain gradient it experiences. This could be a major breakthrough in orthopaedic implant design.We will improve upon our findings to demonstrate control of bone strains and fixation for a compartmental knee replacement, prototype configuration, with additively manufactured lattice parts. So far in this project our aims have been set as extracting anisotropic stiffness of bone based on CT data, validating this in human cadaveric bone and additively manufacturing components which are matched to this.In the past 4 months progress has been made in extracting fabric tensors and density data using MATLAB scripts from clinical CT data of human Femurs and Tibias. Scripts have also been written which employ methods found in literature to find stiffness tensors for all CT voxels based on fabric and density data. Next efforts will seek to generate specimen specific cutting guides for the removal of cores from bone and validate our current stiffness tensor scripts against micro-CT scans (the current gold standard) and cadaveric specimens, via multiaxial mechanical stiffness testing.

在骨科手术中，我们修复、重建或替换部分人体关节。这需要将不同类型的植入物固定在骨头上。骨科植入物的传统制造是由固体钛CoCrMo合金或陶瓷制成的，它们比骨头硬很多倍。但是骨头是一种对拉力有反应的材料，因此这些材料有局限性。我们研究小组令人兴奋的新工作已经证明，我们可以制造与骨骼相同刚度的增材制造（AM）晶格部件，并且骨骼形成已通过其经历的应变梯度在动物模型中得到控制。这可能是骨科植入物设计的重大突破。我们将改进我们的研究结果，以证明骨应变控制和固定的间隔性膝关节置换术，原型配置，添加制造的晶格部件。到目前为止，在这个项目中，我们的目标是基于CT数据提取骨骼的各向异性刚度，并在人体尸体骨骼和与之匹配的增材制造部件中进行验证。在过去的4个月里，利用MATLAB脚本从人体股骨和胫骨的临床CT数据中提取织物张量和密度数据取得了进展。还编写了脚本，其中使用文献中发现的方法来查找基于织物和密度数据的所有CT体素的刚度张量。接下来的工作将寻求生成特定于标本的切割指南，用于从骨骼中去除核心，并通过多轴机械刚度测试，通过微ct扫描（当前的金标准）和尸体标本验证我们当前的刚度张量脚本。