Enhanced and highly specific delivery of small interfering RNA and oligonucleotides as therapeutics for gene silencing

增强和高度特异性地递送小干扰 RNA 和寡核苷酸作为基因沉默的治疗剂

• 批准号: nhmrc : 1054011
• 负责人: Dr Simon Ting
• 金额: $ 20.79万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhanced-highly-specific-gene-silencing/112361
• 关键词: Enhanced; highly; specific; delivery; small

This proposal aims to develop glyco-nanocarriers for the efficient and specific delivery of siRNA/oligonucleotides to treat liver diseases. Complex glycopolymer architectures developed here will protect desired genes from enzymatic degradation and will deliver the gene to the liver specifically for therapy, hence providing a solution towards nucleic acid therapy.

该提案旨在开发用于有效和特异性递送siRNA/寡核苷酸以治疗肝脏疾病的糖纳米载体。这里开发的复杂的糖聚合物结构将保护所需的基因免受酶促降解，并将基因特异性地递送到肝脏用于治疗，因此提供了核酸治疗的解决方案。