A MURINE MODEL FOR PLAQUE RUPTURE
A MURINE MODEL FOR PLAQUE RUPTURE
批准号:
6544889
负责人:
Stephen MARK Schwartz
金额:
$3.12万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-30 至 2002-09-30
关键词:
apolipoprotein E apoptosis atherosclerosis atherosclerotic plaque bone marrow transplantation cell death cholesterol cholesterol esters clinical research cysteine endopeptidases disease /disorder model gene targeting genetically modified animals laboratory mouse low density lipoprotein receptor macrophage model design /development oxidized lipid pathologic process terminal nick end labeling transport proteins
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DESCRIPTION (provided by applicant): This is an application for support for an ongoing program devoted to final events in atherosclerosis, that is rupture of the atherosclerotic plaque. The hypothesis explored is that macrophage death plays a critical role in progression of the lesion. To test this hypothesis, we propose a combination of an in vitro assay designed to identify genes controlling macrophage death and an animal model already demonstrated to show spontaneous plaque rupture. Work done under this program has the potential to identify novel therapeutic approaches to dealing with the progression from existing atherosclerotic lesions to atherosclerotic lesions that become clinically significant.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model.
细胞 FLICE 抑制蛋白在人冠状动脉和大鼠血管损伤模型中的表达。
DOI:
10.1016/s0002-9440(10)64712-8
发表时间:
2000
期刊:
The American journal of pathology
影响因子:
--
作者:
[Imanishi,T, McBride,J, Ho,Q, O'Brien,KD, Schwartz,SM, Han,DK]
通讯作者:
Han,DK
VASCULATA 2014
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批准号:8785015
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项目类别:
-
资助金额:$1.0万
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财政年份:2014
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负责人:Stephen MARK Schwartz
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依托单位:
IMMUNOGENETICS OF HPV-RELATED CANCERS
-
批准号:8307529
-
项目类别:
-
资助金额:$27.5万
-
财政年份:2011
-
负责人:Stephen MARK Schwartz
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依托单位:
VASCULATA V - 2008: the basic science of cardiovascular disease, including the in
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批准号:7545808
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项目类别:
-
资助金额:$1.0万
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财政年份:2008
-
负责人:Stephen MARK Schwartz
-
依托单位:
IMMUNOGENETICS OF HPV-RELATED CANCERS
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批准号:7300322
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项目类别:
-
资助金额:$27.18万
-
财政年份:2007
-
负责人:Stephen MARK Schwartz
-
依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
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批准号:6668562
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项目类别:
-
资助金额:$241.34万
-
财政年份:2002
-
负责人:Stephen MARK Schwartz
-
依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
-
批准号:7105585
-
项目类别:
-
资助金额:$210.43万
-
财政年份:2002
-
负责人:Stephen MARK Schwartz
-
依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
-
批准号:6570065
-
项目类别:
-
资助金额:$202.6万
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财政年份:2002
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负责人:Stephen MARK Schwartz
-
依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
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批准号:6575709
-
项目类别:
-
资助金额:$6.54万
-
财政年份:2002
-
负责人:Stephen MARK Schwartz
-
依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
-
批准号:6793153
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项目类别:
-
资助金额:$252.39万
-
财政年份:2002
-
负责人:Stephen MARK Schwartz
-
依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
-
批准号:6944351
-
项目类别:
-
资助金额:$247.14万
-
财政年份:2002
-
负责人:Stephen MARK Schwartz
-
依托单位:
Critical Role of Macrophage Death in Plaque Progression
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批准号:6678752
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项目类别:
-
资助金额:$40.52万
-
财政年份:2002
-
负责人:Stephen MARK Schwartz
-
依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
-
批准号:6302082
-
项目类别:
-
资助金额:$17.71万
-
财政年份:2000
-
负责人:Stephen MARK Schwartz
-
依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
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批准号:6389652
-
项目类别:
-
资助金额:$36.55万
-
财政年份:1999
-
负责人:Stephen MARK Schwartz
-
依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
-
批准号:6109237
-
项目类别:
-
资助金额:$17.71万
-
财政年份:1999
-
负责人:Stephen MARK Schwartz
-
依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
-
批准号:6537307
-
项目类别:
-
资助金额:$37.51万
-
财政年份:1999
-
负责人:Stephen MARK Schwartz
-
依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
-
批准号:2854246
-
项目类别:
-
资助金额:$33.02万
-
财政年份:1999
-
负责人:Stephen MARK Schwartz
-
依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
-
批准号:6184121
-
项目类别:
-
资助金额:$34.26万
-
财政年份:1999
-
负责人:Stephen MARK Schwartz
-
依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
-
批准号:6272473
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项目类别:
-
资助金额:$18.87万
-
财政年份:1998
-
负责人:Stephen MARK Schwartz
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依托单位:
MYOCARDIAL INFARCT: YOUNG WOMEN: PLASMA HOMOCYSTEINE, FOLATE, MTHFR GENE VARIANT
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批准号:6277357
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项目类别:
-
资助金额:$5.66万
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财政年份:1998
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负责人:Stephen MARK Schwartz
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依托单位:
CELL SURVIVAL PATHWAYS
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批准号:6390192
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项目类别:
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资助金额:$32.36万
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财政年份:1998
-
负责人:Stephen MARK Schwartz
-
依托单位:
国内基金
海外基金
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