Critical Role of Macrophage Death in Plaque Progression
Critical Role of Macrophage Death in Plaque Progression
批准号:
6678752
负责人:
Stephen MARK Schwartz
金额:
$40.52万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-09-30 至 2007-08-31
关键词:
apolipoprotein E apoptosis atherosclerosis atherosclerotic plaque bone marrow transplantation cell death coagulation factor V disease /disorder model gene expression gene targeting genetically modified animals genome in situ hybridization laboratory mouse low density lipoprotein receptor macrophage microarray technology model design /development monocyte morphometry pathologic process phenotype terminal nick end labeling tissue /cell culture vascular endothelium
中文摘要
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英文摘要
This is an application for support for an ongoing program devoted to final events in atherosclerosis, that is rupture of the atherosclerotic plaque. The hypothesis explored is that macrophage death plays a critical role in progression of the lesion. To test this hypothesis, we propose a combination of an in vitro assay designed to identify genes controlling macrophage death and an animal model already demonstrated to show spontaneous plaque rupture. Work done under this program has the potential to identify novel therapeutic approaches to dealing with the progression from existing atherosclerotic lesions to atherosclerotic lesions that
become clinically significant.
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VASCULATA 2014
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批准号:8785015
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项目类别:
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资助金额:$1.0万
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财政年份:2014
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负责人:Stephen MARK Schwartz
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依托单位:
IMMUNOGENETICS OF HPV-RELATED CANCERS
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批准号:8307529
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项目类别:
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资助金额:$27.5万
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财政年份:2011
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负责人:Stephen MARK Schwartz
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依托单位:
VASCULATA V - 2008: the basic science of cardiovascular disease, including the in
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批准号:7545808
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项目类别:
-
资助金额:$1.0万
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财政年份:2008
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负责人:Stephen MARK Schwartz
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依托单位:
IMMUNOGENETICS OF HPV-RELATED CANCERS
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批准号:7300322
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项目类别:
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资助金额:$27.18万
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财政年份:2007
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负责人:Stephen MARK Schwartz
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依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
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批准号:6668562
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项目类别:
-
资助金额:$241.34万
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财政年份:2002
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负责人:Stephen MARK Schwartz
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依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
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批准号:7105585
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项目类别:
-
资助金额:$210.43万
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财政年份:2002
-
负责人:Stephen MARK Schwartz
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依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
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批准号:6570065
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项目类别:
-
资助金额:$202.6万
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财政年份:2002
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负责人:Stephen MARK Schwartz
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依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
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批准号:6575709
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项目类别:
-
资助金额:$6.54万
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财政年份:2002
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负责人:Stephen MARK Schwartz
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依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
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批准号:6793153
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项目类别:
-
资助金额:$252.39万
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财政年份:2002
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负责人:Stephen MARK Schwartz
-
依托单位:
GENOMIC AND GENETIC APPROACHES TO PLAQUE RUPTURE
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批准号:6944351
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项目类别:
-
资助金额:$247.14万
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财政年份:2002
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负责人:Stephen MARK Schwartz
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依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
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批准号:6302082
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项目类别:
-
资助金额:$17.71万
-
财政年份:2000
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负责人:Stephen MARK Schwartz
-
依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
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批准号:6389652
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项目类别:
-
资助金额:$36.55万
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财政年份:1999
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负责人:Stephen MARK Schwartz
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依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
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批准号:6109237
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项目类别:
-
资助金额:$17.71万
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财政年份:1999
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负责人:Stephen MARK Schwartz
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依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
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批准号:6537307
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项目类别:
-
资助金额:$37.51万
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财政年份:1999
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负责人:Stephen MARK Schwartz
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依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
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批准号:2854246
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项目类别:
-
资助金额:$33.02万
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财政年份:1999
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负责人:Stephen MARK Schwartz
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依托单位:
PROPERTIES OF THE INTIMAL SMOOTH MUSCLE CELL
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批准号:6184121
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项目类别:
-
资助金额:$34.26万
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财政年份:1999
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负责人:Stephen MARK Schwartz
-
依托单位:
SMOOTH MUSCLE CELL APOPTOSIS
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批准号:6272473
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项目类别:
-
资助金额:$18.87万
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财政年份:1998
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负责人:Stephen MARK Schwartz
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依托单位:
A MURINE MODEL FOR PLAQUE RUPTURE
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批准号:6544889
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项目类别:
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资助金额:$3.12万
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财政年份:1998
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负责人:Stephen MARK Schwartz
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依托单位:
MYOCARDIAL INFARCT: YOUNG WOMEN: PLASMA HOMOCYSTEINE, FOLATE, MTHFR GENE VARIANT
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批准号:6277357
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项目类别:
-
资助金额:$5.66万
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财政年份:1998
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负责人:Stephen MARK Schwartz
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依托单位:
CELL SURVIVAL PATHWAYS
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批准号:6390192
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项目类别:
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资助金额:$32.36万
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财政年份:1998
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负责人:Stephen MARK Schwartz
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依托单位:
国内基金
海外基金
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