Biology, Biomechanics and Atherosclerosis

生物学、生物力学和动脉粥样硬化

• 批准号: 6491560
• 负责人: William Robert Taylor
• 金额: $ 131.37万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6491560
• 关键词: apoptosis; atherosclerosis; atherosclerotic plaque; biomechanics; blood vessel prosthesis; cardiovascular function; clinical research; coronary disorder; electrocardiography; free radical oxygen; genetically modified animals; hemodynamics; human tissue; inflammation; laboratory mouse; magnetic resonance imaging; mechanical stress; method development; oscillatory blood flow; oxidative stress; phenotype; tissue /cell culture; vascular endothelium; vascular smooth muscle

DESCRIPTION (provided by the applicant): Cardiovascular disease remains the number one cause of death in the United States today. In addition to a plethora of genetic and environmental factors, the diet and lifestyle of Western populations continues to have a profound negative impact on the prevalence of atherosclerotic disease. Significant advances have been made in the management and treatment of the clinical sequalae of this disease process. However, many of these treatments are geared towards the management of catastrophic clinical events. Our understanding of the basic biology of the atherosclerotic lesion is still lacking in terms of a complete and fundamental understanding of the basic biology of the atherosclerotic lesion. The proposed Bioengineering Research Partnership (BRP) will be dedicated to establishing a consortium of investigators from Emory University School of Medicine and The Georgia Institute of Technology devoted to obtaining a greater understanding of the biology and engineering of this fundamental problem of great clinical importance. This BRP will expand upon established collaborations to incorporate expertise in basic vascular biology, imaging technologies, fluid mechanics, arterial wall mechanics, cardiac surgery, and interventional cardiology. We shall make use of explanted human hearts obtained from cardiac transplant recipients to provide a unique, model system to study living, human arteries with established atherosclerosis. The in vivo studies will be augmented by a series of cell culture studies designed to explicitly examine the effects of defined mechanical forces on inflammatory responses and apoptosis in a controlled setting. Finally, the impact of placement of clinically used coronary artery stents on the mechanical and subsequent biological responses of the arterial wall will be examined.

描述(由申请人提供)：心血管疾病仍是 当今美国的头号死因是。除了过多的 遗传和环境因素，西方人的饮食和生活方式 人口继续对艾滋病的流行产生深远的负面影响 动脉粥样硬化症。在管理方面取得了重大进展。 以及治疗这一疾病过程中的临床后遗症。然而，许多人 这些治疗方法中有一部分是针对灾难性临床治疗的。 事件。我们对动脉粥样硬化病变的基本生物学的理解是 仍然缺乏对基本情况的全面和根本的了解 动脉粥样硬化病变的生物学。 拟议的生物工程研究伙伴关系(BRP)将致力于 成立一个由埃默里大学学院的调查人员组成的联盟 医学和佐治亚理工学院致力于获得更大的 对生物学和工程学这一基本问题的理解 非常重要的临床意义。本BRP将扩展已建立的合作关系 将基础血管生物学、成像技术、流体 力学、动脉壁力学、心脏外科和介入性 心脏科。我们将利用从心脏获取的移植的人类心脏 移植受者提供了一种独特的、研究活体、人类的模型系统 已建立动脉粥样硬化的动脉。体内研究将是 通过一系列细胞培养研究来加强，旨在明确地 明确的机械力对炎症反应和 受控环境中的细胞凋亡。最后，安置的影响 临床上使用的冠状动脉支架对机械和后续的影响 我们将检查动脉壁的生物反应。